Curcumin as a therapeutic agent in leukemia.
Wilms' tumor 1 (WT1)
cancer
chemotherapeutic agents
curcumin
leukemia
Journal
Journal of cellular physiology
ISSN: 1097-4652
Titre abrégé: J Cell Physiol
Pays: United States
ID NLM: 0050222
Informations de publication
Date de publication:
08 2019
08 2019
Historique:
received:
01
11
2018
accepted:
18
12
2018
pubmed:
5
1
2019
medline:
22
5
2020
entrez:
5
1
2019
Statut:
ppublish
Résumé
Leukemia comprises a group of hematological malignancies responsible for 8% of all cancers and is the most common cancer in children. Despite significant improvements in leukemia treatment, the efficacy of conventional chemotherapeutic agents is low and the disease carries a poor prognosis with frequent relapses and high mortality. Curcumin is a yellow polyphenol compound with diverse pharmacological actions including anticancer, antioxidant, antidiabetic, anti-inflammatory, immunomodulatory, hepatoprotective, lipid-regulating, antidepressant, and antiarthritic. Many cellular and experimental studies have reported the benefits of curcumin in treating leukemia. Curcumin's anticancer effects are exerted via various mechanisms. Here, we review the effects of curcumin on various types of leukemia whilst considering its mechanisms of action.
Substances chimiques
Anti-Inflammatory Agents
0
Antineoplastic Agents
0
Curcumin
IT942ZTH98
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
12404-12414Informations de copyright
© 2019 Wiley Periodicals, Inc.