The GnRH analogues affect novel neuropeptide SMIM20/phoenixin and GPR173 receptor expressions in the female rat hypothalamic-pituitary-gonadal (HPG) axis.
GPR173
Gonadoliberin
Small Integral Membrane Protein 20
buserelin
cetrorelix
phoenixin
Journal
Clinical and experimental pharmacology & physiology
ISSN: 1440-1681
Titre abrégé: Clin Exp Pharmacol Physiol
Pays: Australia
ID NLM: 0425076
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
04
10
2018
revised:
21
11
2018
accepted:
28
12
2018
pubmed:
5
1
2019
medline:
5
1
2019
entrez:
5
1
2019
Statut:
ppublish
Résumé
The recently discovered peptide phoenixin (PNX) and its receptor GPR173 are novel factors that exhibit a large spectrum of regulatory activity, especially when considered as a central modulator of GnRH-related hormonal control of reproductive processes. It has been already proven that GnRH agonists and antagonists can modulate peptidergic signalling in the HPG axis. Despite these findings, there is so far no information regarding the influence of treatment with GnRH analogues on SMIM20/phoenixin signalling in the hypothalamic-pituitary-gonadal axis. In the current study, SMIM20/phoenixin and GPR173 mRNA levels were measured in the hypothalamus, pituitary and ovaries of female rats in the dioestrus phase following treatment with GnRH-R agonist (buserelin) and antagonist (cetrorelix) using quantitative real-time PCR. The serum PNX concentrations were also estimated with ELISA technique. The hypothalamic, hypophyseal and especially ovarian levels of SMIM20 mRNA were increased after both buserelin and cetrorelix administration. The GPR173 expressions were in turn decreased in the hypothalamus and pituitary. Treatment with the GnRH analogues led to the modulation of SMIM20/phoenixin and GPR173 mRNA expression in the female rat hypothalamic-pituitary-gonadal axis. By identifying buserelin and cetrorelix as novel modulators of phoenixin signalling in the animal HPG axis, these results cast new light on the GnRH analogues mode of action and contribute to a better understanding of the mechanisms responsible for the hormonal control of reproduction.
Identifiants
pubmed: 30609107
doi: 10.1111/1440-1681.13061
doi:
Banques de données
GENBANK
['NM_001134639', 'NM_022255.1', 'NM_012512.2', 'SKI2670']
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
350-359Subventions
Organisme : Śląski Uniwersytet Medyczny
ID : grant for Department of Histology KNW-1-064/K/7/I.
Informations de copyright
© 2019 John Wiley & Sons Australia, Ltd.
Références
Kaprara A, Huhtaniemi IT. The hypothalamus-pituitary-gonad axis: tales of mice and men. Metabolism. 2018;86:3-17.
Rudolph LM, Bentley GE, Calandra RS, et al. Peripheral and Central Mechanisms Involved in the Hormonal Control of Male and Female Reproduction. J Neuroendocrinol. 2016;28(7):2-12. https://doi.org/10.1111/jne.12405.
Christensen A, Bentley GE, Cabrera R, et al. Hormonal regulation of female reproduction. Horm Metab Res. 2012;44(8):587-591.
Kim SM, Yoo T, Lee SY. Effect of SKI2670, a novel, orally active, non-peptide GnRH antagonist, on hypothalamic-pituitary-gonadal axis. Life Sci. 2015;139:166-174.
Clarke IJ, Pompolo S. Synthesis and secretion of GnRH. Animal Reprod Sci. 2005;88(1):29-55.
Diamond MP, Carr B, Dmowski WP, et al. Elagolix treatment for endometriosis-associated pain: results from a phase 2, randomized, double-blind, placebo-controlled study. Reprod Sci. 2014;21(3):363-371.
Castellano JM, Gaytan M, Roa J, et al. Expression of KiSS-1 in Rat Ovary: putative Local Regulator of Ovulation? Endocrinology. 2006;147(10):4852-4862.
Krsmanović LZ, Martinez-Fuentes AJ, Arora KK, et al. Local Regulation of Gonadotroph Function by Pituitary Gonadotropin-Releasing Hormone. Endocrinology. 2000;141(3):1187-1195.
Stamatiades GA, Kaiser UB. Gonadotropin regulation by pulsatile GnRH: signaling and gene expression. Mol Cell Endocrinol. 2018;463:131-141.
Jayes FC, Britt JH, Esbenshade KL. Role of gonadotropin-releasing hormone pulse frequency in differential regulation of gonadotropins in the gilt. Biol Reprod. 1997;56(4):1012-1019.
Gan EH, Quinton R. Physiological significance of the rhythmic secretion of hypothalamic and pituitary hormones. Prog Brain Res. 2010;181:111-126.
Flanagan CA, Manilall A. Gonadotropin-Releasing Hormone (GnRH) Receptor Structure and GnRH Binding. Front Endocrinol (Lausanne). 2017;8:274.
Desaulniers AT, Cederberg RA, Lents CA, White BR. Expression and Role of Gonadotropin-Releasing Hormone 2 and Its Receptor in Mammals. Front Endocrinol (Lausanne). 2017;8:269.
Mahutte NG, Ouhilal S. The Hypothalamic-Pituitary-Ovarian Axis and Control of the Menstrual Cycle. In: Falcone T, Hurd W, eds. Clinical Reproductive Medicine and Surgery. St. Louis, MO: Elsevier Health Sciences; 2007:1-16.
Dosouto C, Haahr T, Humaidan P. Gonadotropin-releasing hormone agonist (GnRHa) trigger - State of the art. Reprod Biol. 2017;17(1):1-8.
Kumar P, Sharma A. Gonadotropin-releasing hormone analogs: understanding advantages and limitations. J Hum Reprod Sci. 2014;7(3):170-174.
Rispoli LA, Nett TM. Pituitary gonadotropin-releasing hormone (GnRH) receptor: structure, distribution and regulation of expression. Animal Reprod Sci. 2005;88(1):57-74.
Kiesel LA, Rody A, Greb RR, Szilágyi A. Clinical use of GnRH analogues. Clin Endocrinol (Oxf). 2002;56(6):677-687.
Horvath JE, Toller GL, Schally AV, Bajo AM, Groot K. Effect of long-term treatment with low doses of the LHRH antagonist Cetrorelix on pituitary receptors for LHRH and gonadal axis in male and female rats. Proc Natl Acad Sci USA. 2004;101:4996-5001.
Tan O, Bukulmez O. Biochemistry, molecular biology and cell biology of gonadotropin-releasing hormone antagonists. Curr Opin Obstet Gynecol. 2011;23(4):238-244.
Horvath JE, Bajo AM, Schally AV, Kovacs M, Herbert F, Groot K. Effects of long-term treatment with the luteinizing hormone-releasing hormone (LHRH) agonist Decapeptyl and the LHRH antagonist Cetrorelix on the levels of pituitary LHRH receptors and their mRNA expression in rats. Proc Natl Acad Sci USA. 2002;99(23):15048-15053.
Suszka-Świtek A, Ryszka F, Dolińska B, et al. Pharmacokinetics and Bioavailability of the GnRH Analogs in the Form of Solution and Zn2 + -Suspension After Single Subcutaneous Injection in Female Rats. Eur J Drug Metab Pharmacokinet. 2017;42(2):251-259.
Hsieh YY, Chang CC, Tsai HD. Comparisons of Different Dosages of Gonadotropin-Releasing Hormone (GnRH) Antagonist, Short-acting Form and Single, Half-dose, Long-acting Form of GnRH Agonist During Controlled Ovarian Hyperstimulation and in vitro Fertilization. Taiwan J Obstet Gynecol. 2008;47(1):66-74.
Ryszka F, Dolinska B. Pulsatile and sustained peptides release from Zn(II) suspensions. Boll Chim Farm. 2003;142(8):319-323.
Yosten GL, Lyu RM, Hsueh AJ, et al. A novel reproductive peptide, phoenixin. J Neuroendocrinol. 2013;25(2):206-215.
Vasilyev VV, Pernasetti F, Rosenberg SB, et al. Transcriptional activation of the ovine FSH beta gene by GnRH involves multiple signal transduction pathways. Endocrinology. 2002;143:1651-1659.
Vasilyev VV, Lawson MA, Dipaolo D, Webster NJ, Mellon PL. Different signaling pathways control acute induction versus long-term repression of LH beta transcription by GnRH. Endocrinology. 2002;143:3414-3426.
Prinz P, Scharner S, Friedrich T, et al. Central and peripheral expression sites of phoenixin-14 immunoreactivity in rats. Biochem Biophys Res Commun. 2017;493(1):195-201. https://doi.org/10.1016/j.bbrc.2017.09.048.
Stein LM, Tullock CW, Mathews SK, et al. Hypothalamic action of phoenixin to control reproductive hormone secretion in females: importance of the orphan G protein-coupled receptor Gpr173. Am J Physiol Regul Integr Comp Physiol. 2016;311(3):R489-R496.
Matsumoto M, Saito T, Takasaki J, et al. An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system. Biochem Biophys Res Commun. 2000;272:576-582.
Treen AK, Luo V, Belsham DD. Phoenixin Activates Immortalized GnRH and Kisspeptin Neurons Through the Novel Receptor GPR173. Mol Endocrinol. 2016;30(8):872-888.
Ullah K, Ur Rahman T, Wu DD, et al. Phoenixin-14 concentrations are increased in association with luteinizing hormone and nesfatin-1 concentrations in women with polycystic ovary syndrome. Clin Chim Acta. 2017;471:243-247.
Stein LM, Haddock CJ, Samson WK, Kolar GR, Yosten GLC. The phoenixins: from discovery of the hormone to identification of the receptor and potential physiologic actions. Peptides. 2018;106:45-48.
Schalla M, Prinz P, Friedrich T, et al. Phoenixin-14 injected intracerebroventricularly but not intraperitoneally stimulates food intake in rats. Peptides. 2017;96:53-60.
Rocca C, Scavello F, Granieri MC, et al. Phoenixin-14: detection and novel physiological implications in cardiac modulation and cardioprotection. Cell Mol Life Sci. 2018;75:743-756.
Lyu RM, Cowan A, Zhang Y, et al. Phoenixin: a novel brain-gut-skin peptide with multiple bioactivity. Acta Pharmacol Sin. 2018;39(5):770-773. https://doi.org/10.1038/aps.2017.195.
Yeo SH, Colledge WH. The Role of Kiss1 Neurons As Integrators of Endocrine, Metabolic, and Environmental Factors in the Hypothalamic-Pituitary-Gonadal Axis. Front Endocrinol (Lausanne). 2018;9:188.
Brown JL, Roberson M. Novel Insights into Gonadotropin-Releasing Hormone Action in the Pituitary Gonadotrope. Semin Reprod Med. 2017;35(2):130-138.
Sengupta A, Chakrabarti N, Sridaran R. Presence of immunoreactive gonadotropin releasing hormone (GnRH) and its receptor (GnRHR) in rat ovary during pregnancy. Mol Reprod. 2008;75:1031-1044.
Hostetter G, Eaton A, Carnes M, Gildner J, Brownfield MS. Immunocytochemical distribution of luteinizing hormone in rat central nervous system. Neuroendocrinology. 1987;46(3):185-193.
Schirman-Hildesheim TD, Gershon E, Litichever N, et al. Local production of the gonadotropic hormones in the rat ovary. Mol Cell Endocrinol. 2008;282(1-2):32-38.
Lyu RM, Huang XF, Zhang Y, et al. Phoenixin: a novel peptide in rodent sensory ganglia. Neuroscience. 2013;250:622-631.
Telegdy G, Tanaka M, Schally AV. Effects of the LHRH antagonist Cetrorelix on the brain function in mice. Neuropeptides. 2009;43(3):229-234.
Telegdy G, Adamik A, Tanaka M, Schally AV. Effects of the LHRH antagonist Cetrorelix on affective and cognitive functions in rats. Regul Pept. 2010;159(1-3):142-147.
Schally AV, Comaru-Schally AM, Nagy A, et al. Hypothalamic hormones and cancer. Front Neuroendocrinol. 2001;22(4):248-291.
Silveyra P, Lux-Lantos V, Libertun C. Both orexin receptors are expressed in rat ovaries and fluctuate with the estrous cycle: effects of orexin receptor antagonists on gonadotropins and ovulation. Am J Physiol Endocrinol Metab. 2007;293(4):E977-E985.
Herde MK, Geist K, Campbell RE, Herbison AE. Gonadotropin-releasing hormone neurons extend complex highly branched dendritic trees outside the blood-brain barrier. Endocrinology. 2011;152(10):3832-3841.
Prevot V. GnRH neurons directly listen to the periphery. Endocrinology. 2011;152(10):3589-3591.