Molecular evidence of role of vitamin D deficiency in various extraskeletal diseases.
25(OH)D
calcitriol
extra skeletal manifestations
immune response
vitamin D
vitamin D receptor
Journal
Journal of cellular biochemistry
ISSN: 1097-4644
Titre abrégé: J Cell Biochem
Pays: United States
ID NLM: 8205768
Informations de publication
Date de publication:
06 2019
06 2019
Historique:
received:
11
09
2018
accepted:
12
11
2018
pubmed:
5
1
2019
medline:
22
7
2020
entrez:
5
1
2019
Statut:
ppublish
Résumé
Role of vitamin D is not only limited to skeletal system but various other systems of the body, such as immune system, endocrine system, and cardiopulmonary system. It is supported by the confirmations of systems-wide expression of vitamin D receptor (VDR), endocrinal effect of calcitriol, and its role in immune responses. Expression of VDR in various systems, immunoregulatory and hormonal response of vitamin D and deficiency of vitamin D may establish various pathologies in the body. This review provides molecular evidence of relation of vitamin D with extra skeletal.
Sections du résumé
BACKGROUND
Role of vitamin D is not only limited to skeletal system but various other systems of the body, such as immune system, endocrine system, and cardiopulmonary system.
MATERIALS AND METHODS
It is supported by the confirmations of systems-wide expression of vitamin D receptor (VDR), endocrinal effect of calcitriol, and its role in immune responses.
RESULTS
Expression of VDR in various systems, immunoregulatory and hormonal response of vitamin D and deficiency of vitamin D may establish various pathologies in the body.
CONCLUSION
This review provides molecular evidence of relation of vitamin D with extra skeletal.
Substances chimiques
Receptors, Calcitriol
0
VDR protein, human
0
Calcitriol
FXC9231JVH
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
8829-8840Informations de copyright
© 2019 Wiley Periodicals, Inc.