Investigation of the Pentathiepin Functionality as an Inhibitor of Feline Immunodeficiency Virus (FIV) via a Potential Zinc Ejection Mechanism, as a Model for HIV Infection.
Animals
Antiviral Agents
/ chemistry
Binding Sites
Capsid Proteins
/ antagonists & inhibitors
Catalytic Domain
Cats
Cell Line
Crystallography, X-Ray
Density Functional Theory
Humans
Immunodeficiency Virus, Feline
/ drug effects
Lentivirus Infections
/ drug therapy
Models, Biological
Molecular Conformation
Thiepins
/ chemistry
Zinc
/ chemistry
1,2,3,4,5-pentathiepin
FIV
HIV
antiviral agents
nucleocapsid protein
varacin
Journal
ChemMedChem
ISSN: 1860-7187
Titre abrégé: ChemMedChem
Pays: Germany
ID NLM: 101259013
Informations de publication
Date de publication:
19 02 2019
19 02 2019
Historique:
received:
09
11
2018
revised:
24
12
2018
pubmed:
5
1
2019
medline:
26
11
2019
entrez:
5
1
2019
Statut:
ppublish
Résumé
A small diverse library of pentathiepin derivatives were prepared to evaluate their efficacy against the nucleocapsid protein function of the feline immunodeficiency virus (FIV) as a model for HIV, using an in vitro cell culture approach. This study led to the development of nanomolar active compounds with low toxicity.
Identifiants
pubmed: 30609219
doi: 10.1002/cmdc.201800718
doi:
Substances chimiques
Antiviral Agents
0
Capsid Proteins
0
Thiepins
0
Zinc
J41CSQ7QDS
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
454-461Informations de copyright
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.