Peroxiredoxins in Cancer and Response to Radiation Therapies.
NCI-60
TCGA
ionizing radiation
oxidative stress
peroxiredoxin
proteomics
radiation resistance
transcriptomics
Journal
Antioxidants (Basel, Switzerland)
ISSN: 2076-3921
Titre abrégé: Antioxidants (Basel)
Pays: Switzerland
ID NLM: 101668981
Informations de publication
Date de publication:
01 Jan 2019
01 Jan 2019
Historique:
received:
28
11
2018
revised:
23
12
2018
accepted:
25
12
2018
entrez:
6
1
2019
pubmed:
6
1
2019
medline:
6
1
2019
Statut:
epublish
Résumé
Peroxiredoxins have a long-established cellular function as regulators of redox metabolism by catalyzing the reduction of peroxides (e.g., H₂O₂, lipid peroxides) with high catalytic efficiency. This activity is also critical to the initiation and relay of both phosphorylation and redox signaling in a broad range of pathophysiological contexts. Under normal physiological conditions, peroxiredoxins protect normal cells from oxidative damage that could promote oncogenesis (e.g., environmental stressors). In cancer, higher expression level of peroxiredoxins has been associated with both tumor growth and resistance to radiation therapies. However, this relationship between the expression of peroxiredoxins and the response to radiation is not evident from an analysis of data in The Cancer Genome Atlas (TCGA) or NCI60 panel of cancer cell lines. The focus of this review is to summarize the current experimental knowledge implicating this class of proteins in cancer, and to provide a perspective on the value of targeting peroxiredoxins in the management of cancer. Potential biases in the analysis of the TCGA data with respect to radiation resistance are also highlighted.
Identifiants
pubmed: 30609657
pii: antiox8010011
doi: 10.3390/antiox8010011
pmc: PMC6356878
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : NIGMS NIH HHS
ID : T32 GM008169
Pays : United States
Organisme : NCI NIH HHS
ID : F30 CA224968
Pays : United States
Organisme : NIEHS NIH HHS
ID : R33 ES025645
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM119227
Pays : United States
Organisme : NCI NIH HHS
ID : U01 CA215848
Pays : United States
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