Iron Homeostasis in the Lungs-A Balance between Health and Disease.
hypoxia
iron homeostasis
lung diseases
oxygen sensing
Journal
Pharmaceuticals (Basel, Switzerland)
ISSN: 1424-8247
Titre abrégé: Pharmaceuticals (Basel)
Pays: Switzerland
ID NLM: 101238453
Informations de publication
Date de publication:
01 Jan 2019
01 Jan 2019
Historique:
received:
20
11
2018
revised:
23
12
2018
accepted:
25
12
2018
entrez:
6
1
2019
pubmed:
6
1
2019
medline:
6
1
2019
Statut:
epublish
Résumé
A strong mechanistic link between the regulation of iron homeostasis and oxygen sensing is evident in the lung, where both systems must be properly controlled to maintain lung function. Imbalances in pulmonary iron homeostasis are frequently associated with respiratory diseases, such as chronic obstructive pulmonary disease and with lung cancer. However, the underlying mechanisms causing alterations in iron levels and the involvement of iron in the development of lung disorders are incompletely understood. Here, we review current knowledge about the regulation of pulmonary iron homeostasis, its functional importance, and the link between dysregulated iron levels and lung diseases. Gaining greater knowledge on how iron contributes to the pathogenesis of these diseases holds promise for future iron-related therapeutic strategies.
Identifiants
pubmed: 30609678
pii: ph12010005
doi: 10.3390/ph12010005
pmc: PMC6469191
pii:
doi:
Types de publication
Journal Article
Review
Langues
eng
Subventions
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 31003A_15481/1
Organisme : Stiftung für wissenschaftliche Forschung der Universität Zürich
ID : STWF-16-009
Organisme : Deutsche Zentrum für Lungenforschung
ID : 82DZL004A1
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