mTOR: A Cellular Regulator Interface in Health and Disease.
Aging
/ drug effects
Animals
Autoimmune Diseases
/ drug therapy
Diabetes Mellitus
/ drug therapy
Humans
Mechanistic Target of Rapamycin Complex 1
/ antagonists & inhibitors
Mechanistic Target of Rapamycin Complex 2
/ antagonists & inhibitors
Neoplasms
/ drug therapy
Obesity
/ drug therapy
Signal Transduction
TOR Serine-Threonine Kinases
/ antagonists & inhibitors
aging
autophagy
cancer
kinase
mTOR
phosphorylation
Journal
Cells
ISSN: 2073-4409
Titre abrégé: Cells
Pays: Switzerland
ID NLM: 101600052
Informations de publication
Date de publication:
02 01 2019
02 01 2019
Historique:
received:
10
12
2018
revised:
25
12
2018
accepted:
01
01
2019
entrez:
6
1
2019
pubmed:
6
1
2019
medline:
6
1
2019
Statut:
epublish
Résumé
The mechanistic target of Rapamycin (mTOR) is a ubiquitously-conserved serine/threonine kinase, which has a central function in integrating growth signals and orchestrating their physiologic effects on cellular level. mTOR is the core component of differently composed signaling complexes that differ in protein composition and molecular targets. Newly identified classes of mTOR inhibitors are being developed to block autoimmune diseases and transplant rejections but also to treat obesity, diabetes, and different types of cancer. Therefore, the selective and context-dependent inhibition of mTOR activity itself might come into the focus as molecular target to prevent severe diseases and possibly to extend life span. This review provides a general introduction to the molecular composition and physiologic function of mTOR complexes as part of the Special Issue "2018 Select Papers by
Identifiants
pubmed: 30609721
pii: cells8010018
doi: 10.3390/cells8010018
pmc: PMC6356367
pii:
doi:
Substances chimiques
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
Mechanistic Target of Rapamycin Complex 2
EC 2.7.11.1
TOR Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
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