Attention-deficit/hyperactivity disorder and lifetime cannabis use: genetic overlap and causality.
Journal
Molecular psychiatry
ISSN: 1476-5578
Titre abrégé: Mol Psychiatry
Pays: England
ID NLM: 9607835
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
01
03
2018
accepted:
10
12
2018
revised:
02
11
2018
pubmed:
6
1
2019
medline:
1
4
2021
entrez:
6
1
2019
Statut:
ppublish
Résumé
Attention-deficit/hyperactivity disorder (ADHD) is a severely impairing neurodevelopmental disorder with a prevalence of 5% in children and adolescents and of 2.5% in adults. Comorbid conditions in ADHD play a key role in symptom progression, disorder course and outcome. ADHD is associated with a significantly increased risk for substance use, abuse and dependence. ADHD and cannabis use are partly determined by genetic factors; the heritability of ADHD is estimated at 70-80% and of cannabis use initiation at 40-48%. In this study, we used summary statistics from the largest available meta-analyses of genome-wide association studies (GWAS) of ADHD (n = 53,293) and lifetime cannabis use (n = 32,330) to gain insights into the genetic overlap and causal relationship of these two traits. We estimated their genetic correlation to be r
Identifiants
pubmed: 30610198
doi: 10.1038/s41380-018-0339-3
pii: 10.1038/s41380-018-0339-3
pmc: PMC8025199
mid: NIHMS1601935
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2493-2503Subventions
Organisme : NIMH NIH HHS
ID : R01 MH094469
Pays : United States
Organisme : NIBIB NIH HHS
ID : U54 EB020403
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH109536
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH101519
Pays : United States
Organisme : NIMH NIH HHS
ID : U01 MH109539
Pays : United States
Commentaires et corrections
Type : ErratumIn
Références
Genet Epidemiol. 2016 May;40(4):304-14
pubmed: 27061298
Neuron. 2015 Jun 3;86(5):1189-202
pubmed: 26050039
Eur Heart J. 2015 Jun 14;36(23):1454-62
pubmed: 25825043
Mol Psychiatry. 2019 Apr;24(4):562-575
pubmed: 29892054
J Biol Chem. 2008 Jul 4;283(27):19026-38
pubmed: 18456661
Nature. 2015 Oct 1;526(7571):68-74
pubmed: 26432245
JAMA Psychiatry. 2016 Jul 1;73(7):713-20
pubmed: 27192174
Drug Alcohol Depend. 2008 May 1;95(1-2):90-6
pubmed: 18242878
PLoS Comput Biol. 2015 Apr 17;11(4):e1004219
pubmed: 25885710
Addict Biol. 2016 Jul;21(4):915-23
pubmed: 25752199
Nature. 2012 Nov 1;491(7422):56-65
pubmed: 23128226
BMC Med Genet. 2008 Dec 18;9:113
pubmed: 19094236
Mol Med. 2015 Nov;21(1):717-725
pubmed: 26181631
J Am Acad Child Adolesc Psychiatry. 2011 Jan;50(1):9-21
pubmed: 21156266
Ann N Y Acad Sci. 2001 Jun;931:251-70
pubmed: 11462745
Am J Med Genet B Neuropsychiatr Genet. 2011 Mar;156(2):125-38
pubmed: 21302341
PLoS One. 2010 Jan 21;5(1):e8832
pubmed: 20098672
Ann N Y Acad Sci. 2008 Oct;1141:318-81
pubmed: 18991966
Am J Psychiatry. 2007 Jun;164(6):942-8
pubmed: 17541055
J Abnorm Psychol. 2014 May;123(2):362-374
pubmed: 24886010
Am J Psychiatry. 2005 Sep;162(9):1621-7
pubmed: 16135620
Subst Use Misuse. 2014 Mar;49(4):427-34
pubmed: 24093525
Psychiatry Res. 2008 Sep 30;160(3):237-46
pubmed: 18707766
Eur Arch Psychiatry Clin Neurosci. 2007 Sep;257(6):309-17
pubmed: 17401730
Nat Genet. 2015 Mar;47(3):291-5
pubmed: 25642630
Mol Psychiatry. 2018 May;23(5):1287-1292
pubmed: 28115737
Nat Genet. 2015 Nov;47(11):1236-41
pubmed: 26414676
Psychol Med. 2014 Jul;44(10):2223-9
pubmed: 24107258
Gigascience. 2015 Feb 25;4:7
pubmed: 25722852
Nat Genet. 2012 Mar 18;44(4):369-75, S1-3
pubmed: 22426310
Am J Med Genet B Neuropsychiatr Genet. 2008 Dec 5;147B(8):1345-54
pubmed: 18821565
Hum Genet. 2012 Jun;131(6):917-29
pubmed: 22492058
Nat Genet. 2019 Jan;51(1):63-75
pubmed: 30478444
Addiction. 2010 Mar;105(3):417-30
pubmed: 20402985
J Neurosci. 2013 Jan 2;33(1):244-58
pubmed: 23283338
J Atten Disord. 2020 Jul;24(9):1345-1354
pubmed: 26610741
Mol Psychiatry. 2013 Jul;18(7):806-12
pubmed: 22733124
Biochem Pharmacol. 2008 Jan 1;75(1):98-111
pubmed: 17764662
Eur Child Adolesc Psychiatry. 2017 Jul;26(7):857-867
pubmed: 28185096
Int J Epidemiol. 2015 Apr;44(2):512-25
pubmed: 26050253
Nat Genet. 2018 May;50(5):693-698
pubmed: 29686387
Mol Psychiatry. 2012 Oct;17(10):960-87
pubmed: 22105624
Am J Hum Genet. 2013 Oct 3;93(4):595-606
pubmed: 24035194
Nat Genet. 2013 Jun;45(6):580-5
pubmed: 23715323
Am J Med Genet B Neuropsychiatr Genet. 2016 Jul;171(5):573-88
pubmed: 26184070
Int J Epidemiol. 2017 Dec 1;46(6):1734-1739
pubmed: 28398548
Am J Med Genet B Neuropsychiatr Genet. 2011 Dec;156B(7):835-43
pubmed: 21858920
Nat Genet. 2017 Jul;49(7):1126-1132
pubmed: 28604730
Transl Psychiatry. 2016 Mar 29;6:e769
pubmed: 27023175
Front Psychiatry. 2015 Apr 20;6:47
pubmed: 25941494
Am J Psychiatry. 1995 Nov;152(11):1652-8
pubmed: 7485630
Eur Neuropsychopharmacol. 2018 Oct;28(10):1059-1088
pubmed: 30195575
Br J Psychiatry. 2009 Mar;194(3):204-11
pubmed: 19252145
Curr Top Behav Neurosci. 2012;9:239-72
pubmed: 21989848
Bioinformatics. 2010 Sep 15;26(18):2336-7
pubmed: 20634204
J Stud Alcohol Drugs. 2014 Mar;75(2):211-21
pubmed: 24650814
Biol Psychiatry. 2017 Nov 1;82(9):634-641
pubmed: 27890468
Clin Psychol Rev. 2011 Apr;31(3):328-41
pubmed: 21382538
J Am Acad Child Adolesc Psychiatry. 2013 Mar;52(3):250-63
pubmed: 23452682
Mol Psychiatry. 2016 Oct;21(10):1485
pubmed: 26857599
Arch Gen Psychiatry. 2007 Oct;64(10):1145-52
pubmed: 17909126
Addict Behav. 2014 Aug;39(8):1278-85
pubmed: 24821471
Atten Defic Hyperact Disord. 2010 Dec;2(4):267-89
pubmed: 21432612
Drug Alcohol Depend. 2014 Feb 1;135:88-94
pubmed: 24332802
Epidemiol Psychiatr Sci. 2016 Jun;25(3):255-66
pubmed: 25989844
Genome Res. 2015 Mar;25(3):338-52
pubmed: 25650246