Vision loss and 12-year risk of dementia in older adults: the 3C cohort study.
Cohort study
Dementia
Epidemiology
Vision loss
Journal
European journal of epidemiology
ISSN: 1573-7284
Titre abrégé: Eur J Epidemiol
Pays: Netherlands
ID NLM: 8508062
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
30
04
2018
accepted:
22
12
2018
pubmed:
6
1
2019
medline:
28
5
2019
entrez:
6
1
2019
Statut:
ppublish
Résumé
To analyze the longitudinal relationships between vision loss and the risk of dementia in the first 2 years, from 2 to 4 years and beyond 4 years after inclusion and to determine the roles of depressive symptomatology and engagement in cognitively stimulating activities in these associations. This study is based on the Three-City (3C) study, a population-based cohort of 7736 initially dementia-free participants aged 65 years and over with 12 years of follow-up. Near visual impairment (VI) was measured and distance visual function (VF) loss was self-reported. Dementia was diagnosed and screened over the 12-year period. At baseline, 8.7% had mild near VI, 4.2% had moderate to severe near VI, and 5.3% had distance VF loss. Among the 882 dementia cases diagnosed over the 12-year follow-up period, 140 cases occurred in the first 2 years, 149 from 2 to 4 years and 593 beyond 4 years after inclusion. In Cox multivariate analysis, moderate to severe near VI was associated with an increased risk of dementia in the first 2 years (HR 2.0, 95% CI 1.2-3.3) and from 2 to 4 years (HR 1.8, 95% CI 1.1-3.1) but the association was not significant beyond 4 years after inclusion even if pointing in similar direction (HR 1.3, 95% CI 0.95-1.9). Mild near VI was associated with an increased risk of dementia only in the first 2 years (HR 1.6, 95% CI 1.1-2.5). Moreover, self-reported distance VF loss was associated with an increased risk beyond 4 years after inclusion (HR 1.5, 95% CI 1.1-2.0) but the association was no longer significant after taking into account baseline cognitive performances. Further adjustment for engagement in cognitively stimulating activities only slightly decreased these associations. However, there was an interaction between vision loss and depressive symptomatology, with vision loss associated with dementia only among participants with depressive symptomatology. These results suggest that poor vision, in particular near vision loss, may represent an indicator of dementia risk at short and middle-term, mostly in depressed elderly people.
Identifiants
pubmed: 30610413
doi: 10.1007/s10654-018-00478-y
pii: 10.1007/s10654-018-00478-y
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
141-152Investigateurs
Geir Bertelsen
(G)
Suzanne Cosh
(S)
Audrey Cougnard-Grégoire
(A)
Piers Dawes
(P)
Cécile Delcourt
(C)
Fofi Constantinidou
(F)
Catherine Helmer
(C)
M Arfan Ikram
(M)
Caroline C W Klaver
(CCW)
Iracema Leroi
(I)
Asri Maharani
(A)
Magda Meester-Smor
(M)
Unal Mutlu
(U)
Virginie Nael
(V)
Neil Pendleton
(N)
Henrik Schirmer
(H)
Gindo Tampubolon
(G)
Henning Tiemeier
(H)
Therese von Hanno
(T)
Références
J Psychiatr Res. 1975 Nov;12(3):189-98
pubmed: 1202204
J Formos Med Assoc. 2003 Feb;102(2):86-90
pubmed: 12709736
Neuroepidemiology. 2003 Nov-Dec;22(6):316-25
pubmed: 14598854
J Am Geriatr Soc. 2004 Dec;52(12):1996-2002
pubmed: 15571533
J Am Geriatr Soc. 2005 Mar;53(3):374-80
pubmed: 15743277
J Am Geriatr Soc. 2005 Apr;53(4):681-6
pubmed: 15817017
Am J Ophthalmol. 2005 Oct;140(4):618-27
pubmed: 16226514
Ophthalmology. 2005 Dec;112(12):2227-37
pubmed: 16325714
Arch Ophthalmol. 2006 Apr;124(4):537-43
pubmed: 16606880
Gerontology. 2006;52(6):386-94
pubmed: 16921251
Arch Ophthalmol. 2009 May;127(5):667-73
pubmed: 19433718
Neurology. 2009 Sep 15;73(11):854-61
pubmed: 19752452
Am J Epidemiol. 2010 Mar 15;171(6):728-35
pubmed: 20150357
Br J Ophthalmol. 2011 Jan;95(1):24-7
pubmed: 20829322
Neurobiol Aging. 2012 Feb;33(2):423.e15-25
pubmed: 21074901
Arch Neurol. 2011 Feb;68(2):214-20
pubmed: 21320988
Arch Ophthalmol. 2012 Jul;130(7):895-900
pubmed: 22410630
J Affect Disord. 2013 Oct;151(1):164-70
pubmed: 23787409
BMJ Open. 2013 Aug 29;3(8):e002998
pubmed: 23988362
Front Hum Neurosci. 2013 Dec 16;7:837
pubmed: 24379769
JAMA Otolaryngol Head Neck Surg. 2014 Apr;140(4):293-302
pubmed: 24604103
BMC Public Health. 2014 Aug 08;14:815
pubmed: 25103270
Lancet Glob Health. 2013 Dec;1(6):e339-49
pubmed: 25104599
Br J Ophthalmol. 2015 Aug;99(8):1017-21
pubmed: 25722491
JAMA Psychiatry. 2015 Jun;72(6):612-9
pubmed: 25875310
J Am Geriatr Soc. 2015 Apr;63(4):692-8
pubmed: 25900484
PLoS One. 2016 Jan 25;11(1):e0147646
pubmed: 26808979
Medicine (Baltimore). 2016 Jan;95(3):e2423
pubmed: 26817872
Biores Open Access. 2016 Aug 01;5(1):228-34
pubmed: 27610269
J Am Geriatr Soc. 2016 Oct;64(10):1981-1987
pubmed: 27611845
N Z Med J. 2017 Aug 11;130(1460):33-47
pubmed: 28796770
JAMA Ophthalmol. 2017 Sep 1;135(9):963-970
pubmed: 28817745
Int Psychogeriatr. 2019 Jan;31(1):139-145
pubmed: 29798742
JAMA Ophthalmol. 2019 Jan 1;137(1):3-11
pubmed: 30326038
Br J Psychiatry. 1973 Oct;123(575):467-70
pubmed: 4748864
Neurology. 1984 Jul;34(7):939-44
pubmed: 6610841
Psychol Aging. 1994 Sep;9(3):339-55
pubmed: 7999320
Psychol Aging. 1997 Mar;12(1):12-21
pubmed: 9100264
Am J Public Health. 1999 Jan;89(1):85-7
pubmed: 9987472