Effects of a common pharmaceutical, atorvastatin, on energy metabolism and detoxification mechanisms of a marine bivalve Mytilus edulis.


Journal

Aquatic toxicology (Amsterdam, Netherlands)
ISSN: 1879-1514
Titre abrégé: Aquat Toxicol
Pays: Netherlands
ID NLM: 8500246

Informations de publication

Date de publication:
Mar 2019
Historique:
received: 21 11 2018
revised: 27 12 2018
accepted: 28 12 2018
pubmed: 6 1 2019
medline: 9 3 2019
entrez: 6 1 2019
Statut: ppublish

Résumé

Biologically active compounds from pharmaceuticals cause concern due to their common occurrence in water and sediments of urbanized coasts and potential threat to marine organisms. Atorvastatin (ATO), a globally prescribed drug, is environmentally stable and bioavailable to marine organisms; however, the physiological and toxic effects of this drug on ecologically important coastal species are yet to be elucidated. We studied the effect of ATO (˜1.2 μg L

Identifiants

pubmed: 30610964
pii: S0166-445X(18)31035-X
doi: 10.1016/j.aquatox.2018.12.022
pii:
doi:

Substances chimiques

ATP Binding Cassette Transporter, Subfamily B, Member 1 0
RNA, Messenger 0
Water Pollutants, Chemical 0
Atorvastatin A0JWA85V8F

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

47-61

Informations de copyright

Copyright © 2018 Elsevier B.V. All rights reserved.

Auteurs

Halina Falfushynska (H)

Department of Marine Biology, Institute of Biological Sciences, University of Rostock, Rostock, Germany; Department of Human Health, Physical Rehabilitation and Vital Activity, Ternopil V. Hnatiuk National Pedagogical University, Ternopil, Ukraine.

Eugene P Sokolov (EP)

Leibniz Institute for Baltic Sea Research, Leibniz ScienceCampus Phosphorus Research Rostock, Warnemünde, Germany.

Fouzia Haider (F)

Department of Marine Biology, Institute of Biological Sciences, University of Rostock, Rostock, Germany.

Christina Oppermann (C)

Department of Industrial Chemistry, Institute of Chemistry, University of Rostock, Rostock, Germany.

Udo Kragl (U)

Department of Industrial Chemistry, Institute of Chemistry, University of Rostock, Rostock, Germany.

Wolfgang Ruth (W)

Department of Industrial Chemistry, Institute of Chemistry, University of Rostock, Rostock, Germany.

Marius Stock (M)

Department of Marine Biology, Institute of Biological Sciences, University of Rostock, Rostock, Germany.

Sabrina Glufke (S)

Department of Marine Biology, Institute of Biological Sciences, University of Rostock, Rostock, Germany.

Eileen J Winkel (EJ)

Department of Marine Biology, Institute of Biological Sciences, University of Rostock, Rostock, Germany.

Inna M Sokolova (IM)

Department of Marine Biology, Institute of Biological Sciences, University of Rostock, Rostock, Germany; Department of Maritime Systems, Interdisciplinary Faculty, University of Rostock, Rostock, Germany. Electronic address: Inna.Sokolova@uni-rostock.de.

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Classifications MeSH