Actin Post-translational Modifications: The Cinderella of Cytoskeletal Control.

Actins / chemistry Animals Cytoskeleton / metabolism Humans Microfilament Proteins / metabolism Protein Processing, Post-Translational
N-terminal modifications acetylation actin cytoskeleton oxidation post-translational modifications

Journal

Trends in biochemical sciences
ISSN: 0968-0004
Titre abrégé: Trends Biochem Sci
Pays: England
ID NLM: 7610674

Informations de publication

Date de publication:
06 2019
Historique:
received: 22 09 2018
revised: 22 11 2018
accepted: 27 11 2018
pubmed: 7 1 2019
medline: 18 12 2019
entrez: 7 1 2019
Statut: ppublish

Résumé

Actin is one of the most abundant proteins in eukaryotic cells and the main component of the microfilament system. It plays essential roles in numerous cellular activities, including muscle contraction, maintenance of cell integrity, and motility, as well as transcriptional regulation. Besides interacting with various actin-binding proteins (ABPs), proper actin function is regulated by post-translational modifications (PTMs), such as acetylation, arginylation, oxidation, and others. Here, we explain how actin PTMs can contribute to filament formation and stability, and may have additional actin regulatory functions, which potentially contribute to disease development.

Identifiants

DOI: 10.1016/j.tibs.2018.11.010 PMID: 30611609
pubmed: 30611609
pii: S0968-0004(18)30259-7
doi: 10.1016/j.tibs.2018.11.010
pii:
doi:

Substances chimiques

Actins 0
Microfilament Proteins 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

502-516

Informations de copyright

Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.

Auteurs

Sylvia Varland (S)

Department of Biomedicine, University of Bergen, Jonas Lies vei 91, N-5020 Bergen, Norway; Department of Biological Sciences, University of Bergen, Thormøhlensgate 53 A, N-5020 Bergen, Norway; Donnelly Centre for Cellular and Biomolecular Research, University of Toronto, 160 College Street, Toronto, ON M5S 3E1, Canada.

Joël Vandekerckhove (J)

Department of Biochemistry, UGent Center for Medical Biotechnology, Ghent University, Albert Baertsoenkaai 3, 9000 Gent, Belgium.

Adrian Drazic (A)

Department of Biomedicine, University of Bergen, Jonas Lies vei 91, N-5020 Bergen, Norway. Electronic address: adrian.drazic@uib.no.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Actines › Actin Post-translational Modifications: The...
questionsmedicales.fr › Eucaryotes › Animaux › Actin Post-translational Modifications: The...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Cytosquelette › Actin Post-translational Modifications: The...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Actin Post-translational Modifications: The...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines du cytosquelette › Protéines des microfilaments › Actin Post-translational Modifications: The...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Modification traductionnelle des protéines › Maturation post-traductionnelle des protéines › Actin Post-translational Modifications: The...