The midbrain periaqueductal gray as an integrative and interoceptive neural structure for breathing.
Breathlessness
Interoception
Periaqueductal gray
Respiration
Journal
Neuroscience and biobehavioral reviews
ISSN: 1873-7528
Titre abrégé: Neurosci Biobehav Rev
Pays: United States
ID NLM: 7806090
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
10
08
2018
revised:
08
11
2018
accepted:
18
12
2018
pubmed:
7
1
2019
medline:
12
7
2019
entrez:
7
1
2019
Statut:
ppublish
Résumé
The periaqueductal gray (PAG) plays a critical role in autonomic function and behavioural responses to threatening stimuli. Recent evidence has revealed the PAG's potential involvement in the perception of breathlessness, a highly threatening respiratory symptom. In this review, we outline the current evidence in animals and humans on the role of the PAG in respiratory control and in the perception of breathlessness. While recent work has unveiled dissociable brain activity within the lateral PAG during perception of breathlessness and ventrolateral PAG during conditioned anticipation in healthy humans, this is yet to be translated into diseases dominated by breathlessness symptomology, such as chronic obstructive pulmonary disease. Understanding how the sub-structures of the PAG differentially interact with interoceptive brain networks involved in the perception of breathlessness will help towards understanding discordant symptomology, and may reveal treatment targets for those debilitated by chronic and pervasive breathlessness.
Identifiants
pubmed: 30611797
pii: S0149-7634(18)30606-7
doi: 10.1016/j.neubiorev.2018.12.020
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
135-144Subventions
Organisme : Medical Research Council
ID : G0802826
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.