A thermo-responsive alginate nanogel platform co-loaded with gold nanoparticles and cisplatin for combined cancer chemo-photothermal therapy.
Alginates
/ administration & dosage
Animals
Antineoplastic Agents
/ administration & dosage
Cell Line, Tumor
Cisplatin
/ administration & dosage
Combined Modality Therapy
Fluorodeoxyglucose F18
Gold
/ administration & dosage
Hyperthermia, Induced
Lasers
Male
Metal Nanoparticles
/ administration & dosage
Mice, Inbred BALB C
Nanogels
/ administration & dosage
Neoplasms
/ diagnostic imaging
Photochemotherapy
Radiopharmaceuticals
Alginate
Chemo-photothermal therapy
Cisplatin
Gold nanoparticles
Positron emission tomography
Journal
Pharmacological research
ISSN: 1096-1186
Titre abrégé: Pharmacol Res
Pays: Netherlands
ID NLM: 8907422
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
05
10
2018
revised:
16
12
2018
accepted:
02
01
2019
pubmed:
7
1
2019
medline:
4
3
2020
entrez:
7
1
2019
Statut:
ppublish
Résumé
The current interest in cancer research is being shifted from individual therapy to combinatorial therapy. In this contribution, a novel multifunctional nanoplatform comprising alginate nanogel co-loaded with cisplatin and gold nanoparticles (AuNPs) has been firstly developed to combine photothermal therapy and chemotherapy. The antitumor efficacy of the as-prepared nanocomplex was tested against CT26 colorectal tumor model. The nanocomplex showed an improved chemotherapy efficacy than free cisplatin and caused a significantly higher tumor inhibition rate. The in vivo thermometry results indicated that the tumors treated with the nanocomplex had faster temperature rise rate under 532 nm laser irradiation and received dramatically higher thermal doses due to optical absorption properties of AuNPs. The combined action of chemo-photothermal therapy using the nanocomplex dramatically suppressed tumor growth up to 95% of control and markedly prolonged the animal survival rate. Moreover, tumor metabolism was quantified by [
Identifiants
pubmed: 30611856
pii: S1043-6618(18)31527-5
doi: 10.1016/j.phrs.2019.01.005
pii:
doi:
Substances chimiques
Alginates
0
Antineoplastic Agents
0
Nanogels
0
Radiopharmaceuticals
0
Fluorodeoxyglucose F18
0Z5B2CJX4D
Gold
7440-57-5
Cisplatin
Q20Q21Q62J
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
178-185Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.