Alcohol-associated antecedent stimuli elicit alcohol seeking in non-dependent rats and may activate the insula.
Alcohol seeking
Cues
Fos
Low dose alcohol
Pavlovian conditioning
Journal
Alcohol (Fayetteville, N.Y.)
ISSN: 1873-6823
Titre abrégé: Alcohol
Pays: United States
ID NLM: 8502311
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
04
01
2018
revised:
22
07
2018
accepted:
10
08
2018
pubmed:
7
1
2019
medline:
28
4
2020
entrez:
7
1
2019
Statut:
ppublish
Résumé
Alcohol self-administration produces brain and behavior adaptations that facilitate a progressive loss of control over drinking and contribute to relapse. One possible adaptation is the ability of antecedent environmental stimuli that are consistently paired with alcohol to trigger alcohol-seeking behaviors. We previously modeled this adaptation in rats using a Pavlovian conditioning procedure in which illumination of a houselight preceded the presentation of a sipper tube that produced unsweetened alcohol when licked. However, in our previous work we did not demonstrate whether this adaptation represented a consequence of repeated exposure to alcohol or the houselight, or whether it was the consequence of associative learning and memory. Thus, in the present study, we tested the associative basis of alcohol seeking in response to houselight illumination in our task using adult male rats that were not food- or water-deprived and were not dependent on alcohol. Separate groups of rats received houselight illumination that was explicitly paired or unpaired with presentation of the retractable sipper that provided access to unsweetened alcohol. Our primary dependent variable was appetitive alcohol-directed behavior: the frequency of movement toward and interaction with the hole in the wall of the chamber through which the sipper was presented during the period of houselight illumination trial before each sipper presentation. However, we also analyzed consummatory sipper licking behavior and blood ethanol concentration in the same rats. Finally, we explored the brain basis of cue-elicited alcohol seeking using c-Fos immunohistochemistry. Our findings confirmed the associative basis of cue-elicited alcohol seeking in our paradigm and mapped these onto the insular cortex, suggesting a role for this brain region in early stages of brain and behavior adaptation to regular alcohol use.
Identifiants
pubmed: 30612041
pii: S0741-8329(18)30002-8
doi: 10.1016/j.alcohol.2018.08.004
pmc: PMC6534119
mid: NIHMS1504036
pii:
doi:
Substances chimiques
Blood Alcohol Content
0
Proto-Oncogene Proteins c-fos
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
91-102Subventions
Organisme : NIMH NIH HHS
ID : R01 MH091147
Pays : United States
Organisme : NIAAA NIH HHS
ID : R37 AA011852
Pays : United States
Organisme : NIAAA NIH HHS
ID : T32 AA007471
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL137030
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Inc. All rights reserved.
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