C4d in Native Glomerular Diseases.
Animals
Complement C4b
/ immunology
Complement Pathway, Classical
/ immunology
Complement Pathway, Mannose-Binding Lectin
/ immunology
Disease Models, Animal
Glomerulonephritis, IGA
/ immunology
Glomerulosclerosis, Focal Segmental
/ immunology
Humans
Kidney Glomerulus
/ immunology
Peptide Fragments
/ immunology
Complement pathways lectin
C4d
Complement pathways classical
Glomerular diseases
Journal
American journal of nephrology
ISSN: 1421-9670
Titre abrégé: Am J Nephrol
Pays: Switzerland
ID NLM: 8109361
Informations de publication
Date de publication:
2019
2019
Historique:
received:
01
09
2018
accepted:
20
11
2018
pubmed:
7
1
2019
medline:
31
3
2020
entrez:
7
1
2019
Statut:
ppublish
Résumé
Complement activation occurs in many glomerular diseases, the exact pathway(s) of activation has been studied in detail in some diseases but not in all. C4d is generated by the activation of classical and lectin pathways, and its presence can point to the activation of either of these pathways. This review aims to summarize the available data with regard to the deposition of glomerular C4d in native kidney biopsies in different glomerular pathologies that may be useful for future research into the role of complement activation in glomerular diseases. While there is more information on C4d in certain diseases (e.g., Immunoglobulin A (IgA) nephropathy), there is scant data in other diseases (such as focal segmental glomerulosclerosis).
Identifiants
pubmed: 30612132
pii: 000496059
doi: 10.1159/000496059
doi:
Substances chimiques
Peptide Fragments
0
Complement C4b
80295-50-7
complement C4d
80295-52-9
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
81-92Informations de copyright
© 2019 S. Karger AG, Basel.