Modified ribavirin analogues as antiviral agents against Junín virus.
1,2,3-Triazole ribose conjugates
Antiviral
Click chemistry
Junín virus
Journal
Bioorganic & medicinal chemistry letters
ISSN: 1464-3405
Titre abrégé: Bioorg Med Chem Lett
Pays: England
ID NLM: 9107377
Informations de publication
Date de publication:
15 02 2019
15 02 2019
Historique:
received:
15
11
2018
revised:
28
12
2018
accepted:
31
12
2018
pubmed:
8
1
2019
medline:
7
3
2020
entrez:
8
1
2019
Statut:
ppublish
Résumé
In this work, several ribavirin analogues were synthesized and incorporated into a multivalent arrangement. Both were subsequently modified by the addition of polyhydroxylated residues. Their antiviral activity was tested against Junín virus, etiological agent responsible of Argentine hemorrhagic fever. Some compounds inhibited Junín virus in the range of 13.2-389.1 µM. Two modified ribavirin analogues presented an effective concentration comparable to ribavirin but with a higher selectivity index.
Identifiants
pubmed: 30612844
pii: S0960-894X(18)31025-4
doi: 10.1016/j.bmcl.2018.12.063
pii:
doi:
Substances chimiques
Antiviral Agents
0
Ribavirin
49717AWG6K
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
556-559Informations de copyright
Copyright © 2019 Elsevier Ltd. All rights reserved.