Cross sectional imaging of truncal and quadriceps muscles relates to different functional outcomes in cancer.
Adult
Aged
Aged, 80 and over
Cachexia
/ complications
Esophageal Neoplasms
/ complications
Female
Humans
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Muscle Strength
/ physiology
Muscle, Skeletal
/ diagnostic imaging
Pancreatic Neoplasms
/ complications
Quadriceps Muscle
Stomach Neoplasms
/ complications
Tomography, X-Ray Computed
/ methods
CT
Function
MRI
Quadriceps
Truncal muscle
Journal
Clinical nutrition (Edinburgh, Scotland)
ISSN: 1532-1983
Titre abrégé: Clin Nutr
Pays: England
ID NLM: 8309603
Informations de publication
Date de publication:
12 2019
12 2019
Historique:
received:
30
10
2018
revised:
15
12
2018
accepted:
18
12
2018
pmc-release:
01
12
2019
pubmed:
8
1
2019
medline:
6
10
2020
entrez:
8
1
2019
Statut:
ppublish
Résumé
Following the consensus definition of cancer cachexia, more studies are using CT scan analysis of truncal muscles as a marker of muscle wasting. However, how CT-derived body composition relates to function, strength and power in patients with cancer is largely unknown. We aimed to describe the relationship between CT truncal (L3) skeletal muscle index (SMI) and MRI quadriceps cross sectional area with lower limb strength, power and measures of complex function. Patients undergoing assessment for potentially curative surgery for oesophagogastric or pancreatic cancer were recruited from the regional upper gastrointestinal (UGI) or hepatopancreaticobiliary (HPB) multi-disciplinary team meetings. Maximum Isometric Knee Extensor Strength (IKES) and Maximum Leg Extensor Power (Nottingham Power Rig) (LEP) were used as measures of lower limb performance. Both Sit to Stand (STS) and Timed Up and Go (TUG) were used as measures of global complex muscle function. Muscle SMI was measured from routine CT scans at the level of the third lumbar vertebrae (L3) and MRI scan was used for the assessment of quadriceps muscles. Linear regression analysis was performed for CT SMI or MRI quadriceps as a predictor of each measure of performance. Forty-four patients underwent assessment. Height and weight were significantly related to function in terms of quadriceps power, while only weight was associated with strength (P < 0.001). CT SMI was not related to measures of quadriceps strength or power but had significant association with more complex functional measures (P = 0.006, R CT SMI and MRI quadriceps have been shown to reflect different aspects of functional ability with CT SMI being a marker of global muscle function and MRI quadriceps being specific to quadriceps power and strength. This should therefore be considered when choosing outcome measures for trials or definitions of muscle mass and function.
Identifiants
pubmed: 30612853
pii: S0261-5614(18)32591-3
doi: 10.1016/j.clnu.2018.12.023
pmc: PMC6876543
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2875-2880Subventions
Organisme : Cancer Research UK
ID : C1128/A7309
Pays : United Kingdom
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Ltd.. All rights reserved.
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