Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.

Animals Anxiety / drug therapy Astrocytes / metabolism Behavior, Animal / drug effects Brain / cytology Cells, Cultured Cellular Senescence / drug effects Cyclin-Dependent Kinase Inhibitor p16 / genetics Dasatinib / pharmacology Diet, High-Fat / adverse effects Disease Models, Animal Female Fibroblasts / metabolism Lipid Droplets Male Mice Mice, Inbred C57BL Mice, Transgenic Neurogenesis Obesity / complications Quercetin / pharmacology Tacrolimus / analogs & derivatives
aging anxiety anxiety-like behavior brain high-fat diet lipid droplets neurogenesis obesity senescence stem cells

Journal

Cell metabolism
ISSN: 1932-7420
Titre abrégé: Cell Metab
Pays: United States
ID NLM: 101233170

Informations de publication

Date de publication:
07 05 2019
Historique:
received: 19 03 2018
revised: 23 10 2018
accepted: 05 12 2018
pubmed: 8 1 2019
medline: 14 7 2020
entrez: 8 1 2019
Statut: ppublish

Résumé

Cellular senescence entails a stable cell-cycle arrest and a pro-inflammatory secretory phenotype, which contributes to aging and age-related diseases. Obesity is associated with increased senescent cell burden and neuropsychiatric disorders, including anxiety and depression. To investigate the role of senescence in obesity-related neuropsychiatric dysfunction, we used the INK-ATTAC mouse model, from which p16

Identifiants

DOI: 10.1016/j.cmet.2018.12.008 PMID: 30612898 PMC: PMC6509403
pubmed: 30612898
pii: S1550-4131(18)30745-9
doi: 10.1016/j.cmet.2018.12.008
pmc: PMC6509403
pii:
doi:

Substances chimiques

AP20187 0
Cdkn2a protein, mouse 0
Cyclin-Dependent Kinase Inhibitor p16 0
Quercetin 9IKM0I5T1E
Dasatinib RBZ1571X5H
Tacrolimus WM0HAQ4WNM

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1061-1077.e8

Subventions

Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/H022384/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R37 AG013925
Pays : United States
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/F010966/1
Pays : United Kingdom
Organisme : Biotechnology and Biological Sciences Research Council
ID : BB/I020748/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P020941/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L016354/1
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG013925
Pays : United States
Organisme : Cancer Research UK
ID : C12161/A24009
Pays : United Kingdom

Commentaires et corrections

Type : ErratumIn

Informations de copyright

Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

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Auteurs

Mikolaj Ogrodnik (M)

Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Yi Zhu (Y)

Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Larissa G P Langhi (LGP)

Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Tamar Tchkonia (T)

Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Patrick Krüger (P)

Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.

Edward Fielder (E)

Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.

Stella Victorelli (S)

Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.

Rifqha A Ruswhandi (RA)

Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK.

Nino Giorgadze (N)

Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Tamar Pirtskhalava (T)

Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Oleg Podgorni (O)

Department of Anesthesiology, Stony Brook School of Medicine, 101 Nicolls Road, Stony Brook, New York, NY 11794, USA; Center for Developmental Genetics, Stony Brook University, 100 Nicolls Road, Stony Brook, New York, NY 11794, USA.

Grigori Enikolopov (G)

Department of Anesthesiology, Stony Brook School of Medicine, 101 Nicolls Road, Stony Brook, New York, NY 11794, USA; Center for Developmental Genetics, Stony Brook University, 100 Nicolls Road, Stony Brook, New York, NY 11794, USA; Department of Nano-, Bio-, Information Technology and Cognitive Science, Moscow Institute of Physics and Technology, Moscow, Russia; Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, NY, USA.

Kurt O Johnson (KO)

Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Ming Xu (M)

Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Christine Inman (C)

Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Allyson K Palmer (AK)

Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Marissa Schafer (M)

Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Moritz Weigl (M)

Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

Yuji Ikeno (Y)

The Barshop Institute for Longevity and Aging Studies, San Antonio, Department of Pathology, The University of Texas Health Science Center at San Antonio, Research Service, Audie L. Murphy VA Hospital (STVHCS), San Antonio, TX 78229, USA.

Terry C Burns (TC)

Departments of Neurologic Surgery and Neuroscience, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA.

João F Passos (JF)

Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA.

Thomas von Zglinicki (T)

Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK; Near East University, Arts and Sciences Faculty, Molecular Biology and Genetics, Nicosia, North Cyprus POB 99138 Mersin 10, Turkey.

James L Kirkland (JL)

Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. Electronic address: kirkland.james@mayo.edu.

Diana Jurk (D)

Institute for Cell and Molecular Biosciences, Newcastle University Institute for Ageing, Campus for Ageing and Vitality, Newcastle upon Tyne NE4 5PL, UK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA; Department of Physiology and Biomedical Engineering, Mayo Clinic, Rochester, MN 55905, USA. Electronic address: diana.jurk1@ncl.ac.uk.

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Obesity-Induced Cellular Senescence Drives...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Émotions › Anxiété › Obesity-Induced Cellular Senescence Drives...
questionsmedicales.fr › Cellules › Névroglie › Astrocytes › Obesity-Induced Cellular Senescence Drives...
questionsmedicales.fr › Comportement et mécanismes comportementaux › Comportement › Comportement animal › Obesity-Induced Cellular Senescence Drives...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Obesity-Induced Cellular Senescence Drives...
questionsmedicales.fr › Cellules › Cellules cultivées › Obesity-Induced Cellular Senescence Drives...
questionsmedicales.fr › Phénomènes physiologiques › Croissance et développement › Vieillissement › Vieillissement de la cellule › Obesity-Induced Cellular Senescence Drives...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines suppresseurs de tumeurs › Protéines inhibitrices des kinases cyclines-dépendantes › Inhibiteur p16 de kinase cycline-dépendante › Obesity-Induced Cellular Senescence Drives...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyrimidines › Dasatinib › Obesity-Induced Cellular Senescence Drives...
questionsmedicales.fr › Phénomènes physiologiques › Alimentation et nutrition › Phénomènes physiologiques nutritionnels › Régime alimentaire › Alimentation riche en graisse › Obesity-Induced Cellular Senescence Drives...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles biologiques › Modèles animaux de maladie humaine › Obesity-Induced Cellular Senescence Drives...
questionsmedicales.fr › Cellules › Cellules du tissu conjonctif › Fibroblastes › Obesity-Induced Cellular Senescence Drives...
questionsmedicales.fr › Cellules › Structures cellulaires › Espace intracellulaire › Cytoplasme › Structures cytoplasmiques › Organites › Gouttelettes lipidiques › Obesity-Induced Cellular Senescence Drives...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Obesity-Induced Cellular Senescence Drives...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée C57BL › Obesity-Induced Cellular Senescence Drives...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Obesity-Induced Cellular Senescence Drives...
questionsmedicales.fr › Phénomènes physiologiques de l'appareil locomoteur et du système nerveux › Phénomènes physiologiques du système nerveux › Neurogenèse › Obesity-Induced Cellular Senescence Drives...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Obésité › Obesity-Induced Cellular Senescence Drives...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Flavonols › Quercétine › Obesity-Induced Cellular Senescence Drives...
questionsmedicales.fr › Composés chimiques organiques › Lactones › Tacrolimus › Obesity-Induced Cellular Senescence Drives...