A certain invariance property of BLUE in a whole-genome regression context.
Journal
Journal of animal breeding and genetics = Zeitschrift fur Tierzuchtung und Zuchtungsbiologie
ISSN: 1439-0388
Titre abrégé: J Anim Breed Genet
Pays: Germany
ID NLM: 100955807
Informations de publication
Date de publication:
Mar 2019
Mar 2019
Historique:
received:
22
10
2018
revised:
03
12
2018
accepted:
06
12
2018
pubmed:
8
1
2019
medline:
13
3
2019
entrez:
8
1
2019
Statut:
ppublish
Résumé
A curious result from mixed linear models applied to genome-wide association studies was expanded. In particular, a model in which one or more markers are considered as fixed but are allowed to contribute to the covariance structure by treating such markers as random as well was examined. The best linear unbiased estimator of marker effects is invariant with respect to whether those markers are employed in constructing a genomic relationship matrix or are ignored, provided marker effects are uncorrelated with those not being tested. Also, the implications of regarding some marker effects as fixed when, in fact, these possess a non-trivial covariance structure with those declared as random were examined.
Identifiants
pubmed: 30614572
doi: 10.1111/jbg.12378
pmc: PMC6850311
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
113-117Informations de copyright
© 2018 The Authors. Journal of Animal Breeding and Genetics published by Blackwell Verlag GmbH.
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