Impact of Therapeutic Interventions on Pain Intensity and Endogenous Pain Modulation in Knee Osteoarthritis: A Systematic Review and Meta-analysis.
Chronic Pain
Conditioned Pain Modulation
Osteoarthritis
Pain Management
Temporal Summation
Journal
Pain medicine (Malden, Mass.)
ISSN: 1526-4637
Titre abrégé: Pain Med
Pays: England
ID NLM: 100894201
Informations de publication
Date de publication:
01 05 2019
01 05 2019
Historique:
pubmed:
8
1
2019
medline:
7
3
2020
entrez:
8
1
2019
Statut:
ppublish
Résumé
To study the impact of therapeutic interventions on pain analgesia and endogenous pain modulation in knee osteoarthritis (KOA). Systematic review and meta-analysis. We searched for KOA randomized clinical trials and observational studies with data on therapeutic interventions comparing pain intensity, temporal summation (TS), and conditioned pain modulation (CPM) scores relative to control. These data were pooled as Hedge's g. To study the relationship between pain intensity and TS/CPM, we performed metaregression with 10,000 Monte-Carlo permutations. We reviewed 11 studies (559 participants). On studying all the interventions together, we found no significant changes in pain modulation, TS, or CPM. Our findings show that this lack of difference is likely because surgical and nonsurgical interventions resulted in contrary effects. Metaregression significantly correlated pain reduction with normalization of TS and CPM. We demonstrate an association between pain reduction and TS/CPM normalization. Though we cannot directly compare these interventions, the results allow us to draw hypotheses on potential practice schemas. Recovering defective endogenous pain modulation mechanisms may help establish long-term analgesia. However, to validate these paradigms as robust clinical biomarkers, further investigation into their mechanisms would be necessary. The registration number for this review is CRD42017072066.
Identifiants
pubmed: 30615173
pii: 5274166
doi: 10.1093/pm/pny261
pmc: PMC6497134
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1000-1011Subventions
Organisme : NCCIH NIH HHS
ID : R01 AT009491
Pays : United States
Organisme : NICHD NIH HHS
ID : R01 HD082302
Pays : United States
Informations de copyright
© 2019 American Academy of Pain Medicine. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
Références
J Pain. 2013 Feb;14(2):114-25
pubmed: 23260452
Neurology. 2004 Sep 14;63(5):848-52
pubmed: 15365135
J Chem Neuroanat. 1998 Dec;16(1):57-72
pubmed: 9924973
Arthritis Care Res (Hoboken). 2014 Dec;66(12):1836-43
pubmed: 24905427
Pain. 2009 Sep;145(1-2):18-23
pubmed: 19524367
Clin J Pain. 2017 Dec;33(12):1081-1087
pubmed: 28277434
Pain. 2015 Jan;156(1):55-61
pubmed: 25599301
Pain. 2010 Jun;149(3):573-81
pubmed: 20418016
PLoS One. 2016 Feb 12;11(2):e0149168
pubmed: 26871954
J Pain. 2012 Oct;13(10):936-44
pubmed: 22981090
Pain. 2000 Oct;88(1):69-78
pubmed: 11098101
PLoS One. 2017 Jun 30;12(6):e0180328
pubmed: 28665989
Pain. 2017 May;158(5):988
pubmed: 28414704
Pain. 2008 Aug 15;138(1):22-8
pubmed: 18079062
Pain. 2015 Apr;156 Suppl 1:S24-31
pubmed: 25789433
Clin Orthop Relat Res. 2010 Jan;468(1):57-63
pubmed: 19844772
Ann Rheum Dis. 2015 Apr;74(4):682-8
pubmed: 24351516
JAMA Intern Med. 2015 Jun;175(6):923-30
pubmed: 25822572
Scand J Rheumatol. 2017 Jul;46(4):303-316
pubmed: 27733091
Osteoarthritis Cartilage. 2015 Jul;23(7):1043-56
pubmed: 25749012
Phys Ther. 2015 Nov;95(11):1582-91
pubmed: 25953594
PLoS One. 2008 Jul 23;3(7):e2742
pubmed: 18648647
Exp Brain Res. 2014 Dec;232(12):3991-9
pubmed: 25183161
Medicine (Baltimore). 2016 Apr;95(17):e3353
pubmed: 27124022
Pain Pract. 2017 Feb;17(2):249-266
pubmed: 27538534
Pain. 2016 Aug;157(8):1704-10
pubmed: 27045524
Neuroscience. 1997 Feb;76(3):845-58
pubmed: 9135056
Baillieres Clin Rheumatol. 1997 Nov;11(4):817-34
pubmed: 9429738
Exp Neurol. 2012 Apr;234(2):271-82
pubmed: 21893056
Pain. 2016 Jul;157(7):1400-6
pubmed: 27331347
Pain. 2016 Nov;157(11):2410-2419
pubmed: 27559835
Pain. 2015 Sep;156(9):1812-25
pubmed: 26090759
Anesthesiology. 2015 Mar;122(3):677-85
pubmed: 25437498
Pain. 2008 Oct 15;139(2):315-23
pubmed: 18538477
Clin J Pain. 2018 Mar;34(3):193-197
pubmed: 28654559
Pain. 2014 Apr;155(4):703-11
pubmed: 24378879
Pain. 2012 Jun;153(6):1193-8
pubmed: 22480803
Osteoarthritis Cartilage. 2013 Sep;21(9):1243-52
pubmed: 23973137
Syst Rev. 2016 Dec 5;5(1):210
pubmed: 27919275
J Pain. 2018 Aug;19(8):819-836
pubmed: 29454976
J Pain. 2004 Mar;5(2):77-82
pubmed: 15042515
Pain Med. 2015 Sep 23;17(5):877-891
pubmed: 26398594
Rheumatology (Oxford). 2016 Jun;55(6):1091-8
pubmed: 26983452
Pain. 2001 Mar;91(1-2):165-75
pubmed: 11240089
Phys Ther. 2012 Jul;92(7):898-910
pubmed: 22466027
Clin J Pain. 2017 May;33(5):395-404
pubmed: 27518487
BMC Musculoskelet Disord. 2015 Feb 12;16:25
pubmed: 25887644
Eur J Pharmacol. 2013 Sep 15;716(1-3):106-19
pubmed: 23500198
Ann Rheum Dis. 2014 Jul;73(7):1323-30
pubmed: 24553908
Mol Pain. 2016 Mar 07;12:
pubmed: 27030712