Cellular Target of a Rhodium Metalloinsertor is the DNA Base Pair Mismatch.

Antineoplastic Agents / chemistry Base Pair Mismatch / drug effects Cell Line, Tumor Colorectal Neoplasms / drug therapy DNA Mismatch Repair / drug effects Humans Molecular Docking Simulation Organometallic Compounds / chemistry Rhodium / chemistry
DNA recognition antitumor agents cancer cellular uptake cytotoxicity

Journal

Chemistry (Weinheim an der Bergstrasse, Germany)
ISSN: 1521-3765
Titre abrégé: Chemistry
Pays: Germany
ID NLM: 9513783

Informations de publication

Date de publication:
26 Feb 2019
Historique:
received: 03 01 2019
pubmed: 8 1 2019
medline: 22 3 2019
entrez: 8 1 2019
Statut: ppublish

Résumé

Defects in DNA mismatch repair (MMR) are commonly found in various cancers, especially in colorectal cancers. Despite the high prevalence of MMR-deficient cancers, mismatch-targeted therapeutics are limited and diagnostic tools are indirect. Here, we examine the cytotoxic properties of a rhodium metalloinsertor, [Rh(phen)(chrysi)(PPO)]

Identifiants

DOI: 10.1002/chem.201900042 PMID: 30615818
pubmed: 30615818
doi: 10.1002/chem.201900042
doi:

Substances chimiques

Antineoplastic Agents 0
Organometallic Compounds 0
Rhodium DMK383DSAC

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

3014-3019

Subventions

Organisme : National Institutes of Health
Organisme : Gordon and Betty Moore Foundation
Organisme : U.S. Department of Defense

Informations de copyright

© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

Auteurs

Kelsey M Boyle (KM)

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 127-72, Pasadena, California, 91125, USA.

Adela Nano (A)

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 127-72, Pasadena, California, 91125, USA.

Catherine Day (C)

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 127-72, Pasadena, California, 91125, USA.

Jacqueline K Barton (JK)

Division of Chemistry and Chemical Engineering, California Institute of Technology, 1200 East California Boulevard, MC 127-72, Pasadena, California, 91125, USA.
ORCID: 0000-0001-9883-1600

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Cellular Target of a Rhodium Metalloinsertor...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Mutation › Mésappariement de bases › Cellular Target of a Rhodium Metalloinsertor...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › Cellular Target of a Rhodium Metalloinsertor...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies gastro-intestinales › Maladies intestinales › Maladies du rectum › Tumeurs colorectales › Cellular Target of a Rhodium Metalloinsertor...
questionsmedicales.fr › Phénomènes génétiques › Réparation de l'ADN › Réparation de mésappariement de l'ADN › Cellular Target of a Rhodium Metalloinsertor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Cellular Target of a Rhodium Metalloinsertor...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Cellular Target of a Rhodium Metalloinsertor...
questionsmedicales.fr › Composés chimiques organiques › Composés organométalliques › Cellular Target of a Rhodium Metalloinsertor...
questionsmedicales.fr › Produits chimiques inorganiques › Métaux › Métaux lourds › Rhodium › Cellular Target of a Rhodium Metalloinsertor...