Intravenous administration of human adipose-derived stem cells ameliorates motor and cognitive function for intracerebral hemorrhage mouse model.
Administration, Intravenous
Animals
Brain
/ physiopathology
Cerebral Hemorrhage
/ pathology
Cognition
/ physiology
Cognitive Dysfunction
/ therapy
Disease Models, Animal
Humans
Male
Mesenchymal Stem Cell Transplantation
/ methods
Mesenchymal Stem Cells
/ metabolism
Mice
Mice, Inbred C57BL
Motor Activity
/ physiology
Motor Skills Disorders
/ therapy
Recovery of Function
Human adipose-derived stem cell
Intracerebral hemorrhage
Macrophage
Neurobehavior
Journal
Brain research
ISSN: 1872-6240
Titre abrégé: Brain Res
Pays: Netherlands
ID NLM: 0045503
Informations de publication
Date de publication:
15 05 2019
15 05 2019
Historique:
received:
09
11
2018
revised:
19
12
2018
accepted:
28
12
2018
pubmed:
8
1
2019
medline:
5
8
2020
entrez:
8
1
2019
Statut:
ppublish
Résumé
Even today, intracerebral hemorrhage (ICH) is a major cause of death and disabilities. Rehabilitation is preferentially applied for functional recovery although its effect is limited. Recent studies have suggested that intravenous administration of mesenchymal stem cells would improve the post-ICH neurological deficits. Human adipose-derived stem cells (hADSCs) have been established in our laboratory. We aimed to evaluate the therapeutic efficacy of the hADSCs on the post-ICH neurological deficits using a clinical-relevant ICH mouse model. We also evaluated immune responses to clarify the underlying mechanisms. The hADSCs expressed MSC markers at high levels. The hADSCs administration into the ICH-bearing mice improved the neurological deficits during the subacute phases, which was shown by neurobehavioral experiments. Besides, the hADSC administration decreased the number of CD11
Identifiants
pubmed: 30615889
pii: S0006-8993(18)30668-1
doi: 10.1016/j.brainres.2018.12.042
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
58-67Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.