Synthesis, characterization, and DFT study of novel metallo phtalocyanines with four carboranyl clusters as photosensitisers for the photodynamic therapy of breast cancer cells.
Cytotox
Density Functional Theory
Metallophthalocyanine
Photodynamic therapy
o‑Carborane
Journal
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
ISSN: 1879-0720
Titre abrégé: Eur J Pharm Sci
Pays: Netherlands
ID NLM: 9317982
Informations de publication
Date de publication:
01 Mar 2019
01 Mar 2019
Historique:
received:
01
10
2018
revised:
03
12
2018
accepted:
24
12
2018
pubmed:
8
1
2019
medline:
10
5
2019
entrez:
8
1
2019
Statut:
ppublish
Résumé
The synthesis and characterization of novel Zn(II) and Co(II) phthalocyanines 4 and 5, respectively containing four o-carboranyl units (40 boron atoms, 32.5% boron by weight) at the peripheral positions are described. The phthalocyanines (Pcs) were synthesized by cyclotetramerization of the previously prepared precursor 4‑(2‑thiol‑o‑carboranyl)thiolato‑phthalonitrile 3 with the presence of metal salt in boiling dry DMF under a dry nitrogen atmosphere. They were characterized by elemental analysis, UV-Vis, FT-IR, MALDI-TOF mass and
Identifiants
pubmed: 30615930
pii: S0928-0987(18)30552-9
doi: 10.1016/j.ejps.2018.12.017
pii:
doi:
Substances chimiques
Indoles
0
Isoindoles
0
Photosensitizing Agents
0
phthalocyanine
V5PUF4VLGY
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
124-131Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.