Structure, DNA/proteins binding, docking and cytotoxicity studies of copper(II) complexes with the first quinolone drug nalidixic acid and 2,2'‑dipyridylamine.
2,2'-Dipyridyl
/ analogs & derivatives
Cell Death
Circular Dichroism
Coordination Complexes
/ chemical synthesis
Copper
/ chemistry
DNA
/ chemistry
Density Functional Theory
Humans
Kinetics
MCF-7 Cells
Molecular Conformation
Molecular Docking Simulation
Nalidixic Acid
/ chemistry
Protein Binding
Serum Albumin, Bovine
/ metabolism
Serum Albumin, Human
/ metabolism
Solubility
Spectrometry, Fluorescence
Spectrophotometry, Ultraviolet
Spectroscopy, Fourier Transform Infrared
Viscosity
Copper complexes
Crystal structure
Cytotoxicity
DFT calculations
DNA and proteins binding studies
Molecular docking studies
Journal
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy
ISSN: 1873-3557
Titre abrégé: Spectrochim Acta A Mol Biomol Spectrosc
Pays: England
ID NLM: 9602533
Informations de publication
Date de publication:
05 Apr 2019
05 Apr 2019
Historique:
received:
02
10
2018
revised:
18
12
2018
accepted:
22
12
2018
pubmed:
8
1
2019
medline:
27
3
2019
entrez:
8
1
2019
Statut:
ppublish
Résumé
This work presents the synthesis, structural characterization and biological affinity of the newly synthesized copper(II) complexes with the first antibacterial quinolone drug nalidixic acid (nal) or N-donor ligand 2,2'‑dipyridylamine (bipyam). [Cu(II)(nal)(bipyam)Cl], (2) reveals a distorted square pyramidal based geometry in Cu(II) atom confirmed by X-ray crystallography technique. The theoretical stabilities and optimized structures of the complex were obtained from DFT calculations. The ability of the complexes to bind with calf thymus DNA (CT DNA) were investigated by electronic absorption, fluorescence, circular dichroism, and viscosity measurements techniques. The experimental results reveal that the complexes strongly interact with CT DNA via intercalative mode but complex 2 exhibits the highest affinity giving K
Identifiants
pubmed: 30616168
pii: S1386-1425(18)31115-6
doi: 10.1016/j.saa.2018.12.045
pii:
doi:
Substances chimiques
Coordination Complexes
0
Serum Albumin, Bovine
27432CM55Q
Nalidixic Acid
3B91HWA56M
2,2'-Dipyridyl
551W113ZEP
Copper
789U1901C5
DNA
9007-49-2
calf thymus DNA
91080-16-9
2,2'-dipyridylamine
X9BF664YAK
Serum Albumin, Human
ZIF514RVZR
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
94-104Informations de copyright
Copyright © 2018. Published by Elsevier B.V.