Reproductive history and risk of nasopharyngeal carcinoma: A population-based case-control study in southern China.
Adult
Aged
Case-Control Studies
China
/ epidemiology
Female
Gravidity
Health Status Disparities
Humans
Incidence
Logistic Models
Menopause
Middle Aged
Nasopharyngeal Carcinoma
/ epidemiology
Nasopharyngeal Neoplasms
/ epidemiology
Odds Ratio
Parity
Parturition
Pregnancy
Risk Factors
Time Factors
Young Adult
Case-control study
Intrinsic hormone exposure
Menopause
Nasopharyngeal carcinoma
Pregnancy
Southern China
Journal
Oral oncology
ISSN: 1879-0593
Titre abrégé: Oral Oncol
Pays: England
ID NLM: 9709118
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
18
08
2018
revised:
21
10
2018
accepted:
18
11
2018
entrez:
9
1
2019
pubmed:
9
1
2019
medline:
9
4
2020
Statut:
ppublish
Résumé
Nasopharyngeal carcinoma (NPC) incidence exhibits a remarkable sex disparity, with higher risk among males. Whether this pattern can be partly explained by female reproductive history is unclear. A population-based case-control study of NPC was conducted in southern China between 2010 and 2014, including 674 histopathologically verified female NPC cases and 690 female controls randomly selected from population-based registries. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression after adjusting for potential confounders. Women who had 3, 4, or ≥5 pregnancies compared with 2 pregnancies were at significantly increased risk for NPC (ORs 1.56, 1.45 and 1.88, respectively). History of deliveries was similarly associated with a greater risk of NPC. These positive associations were more prominent in women who were younger than 50 years, had less than 10 years of education, or were white-collar workers. Increasing time since menopause was associated with a diminished NPC risk (P Contrary to our hypothesis, a history of pregnancy or delivery increased the risk of NPC and the risk decreased with increasing time since menopause. However, the non-linear relationship and no consistent risk patterns across strata indicate that the observed associations are unlikely to be causal, and may at least partially be ascribed to residual confounding by socioeconomic factors.
Identifiants
pubmed: 30616779
pii: S1368-8375(18)30444-5
doi: 10.1016/j.oraloncology.2018.11.025
pmc: PMC6336493
mid: NIHMS1514368
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102-108Subventions
Organisme : NCI NIH HHS
ID : R01 CA115873
Pays : United States
Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
Références
Int J Cancer. 2000 Feb 1;85(3):364-9
pubmed: 10652428
Am J Reprod Immunol. 1982 Aug;2(4):217-21
pubmed: 6291416
Chin J Cancer. 2015 May 14;34(8):350-7
pubmed: 26058679
Cancer Epidemiol Biomarkers Prev. 2016 Aug;25(8):1201-7
pubmed: 27197279
Curr Top Med Chem. 2006;6(2):103-11
pubmed: 16454762
Occup Environ Med. 2006 Jan;63(1):39-44
pubmed: 16361404
Reprod Toxicol. 2008 Aug;25(4):468-71
pubmed: 18534816
Immunogenetics. 2006 Apr;58(2-3):113-21
pubmed: 16547745
Cancer. 2017 Jul 15;123(14):2716-2725
pubmed: 28241094
J Virol. 1996 Oct;70(10):6816-9
pubmed: 8794321
Eur J Cancer. 2013 Jan;49(1):150-5
pubmed: 22892061
BJOG. 2005 Dec;112(12):1620-4
pubmed: 16305564
Science. 2007 Jul 6;317(5834):121-4
pubmed: 17615358
Am J Perinatol. 2010 Oct;27(9):715-9
pubmed: 20387188
Cancer Causes Control. 2015 Jun;26(6):913-21
pubmed: 25822573
J Leukoc Biol. 2002 Sep;72(3):512-21
pubmed: 12223519
Curr Opin Investig Drugs. 2006 Nov;7(11):997-1001
pubmed: 17117588
J Infect Dis. 1983 Jun;147(6):982-6
pubmed: 6304207
BMC Cancer. 2010 Aug 20;10:446
pubmed: 20727127
Oncotarget. 2017 Jul 29;8(50):87073-87085
pubmed: 29152064
Cancer Causes Control. 1999 Jun;10(3):201-7
pubmed: 10454065
Chin J Cancer. 2011 Feb;30(2):79-84
pubmed: 21272439
Vaccine. 2003 Jul 28;21(24):3352-7
pubmed: 12850338
Chin J Cancer. 2010 May;29(5):517-26
pubmed: 20426903