Signaling and Regulation of the Mitochondrial Unfolded Protein Response.
Journal
Cold Spring Harbor perspectives in biology
ISSN: 1943-0264
Titre abrégé: Cold Spring Harb Perspect Biol
Pays: United States
ID NLM: 101513680
Informations de publication
Date de publication:
03 06 2019
03 06 2019
Historique:
pubmed:
9
1
2019
medline:
22
9
2020
entrez:
9
1
2019
Statut:
epublish
Résumé
The mitochondrial proteome encompasses more than a thousand proteins, which are encoded by the mitochondrial and nuclear genomes. Mitochondrial biogenesis and network health relies on maintenance of protein import pathways and the protein-folding environment. Cell-extrinsic or -intrinsic stressors that challenge mitochondrial proteostasis negatively affect organellar function. During conditions of stress, cells use impaired protein import as a sensor for mitochondrial dysfunction to activate a stress response called the mitochondrial unfolded protein response (UPR
Identifiants
pubmed: 30617048
pii: cshperspect.a033944
doi: 10.1101/cshperspect.a033944
pmc: PMC6546047
pii:
doi:
Substances chimiques
Mitochondrial Proteins
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIA NIH HHS
ID : R01 AG040061
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG047182
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Informations de copyright
Copyright © 2019 Cold Spring Harbor Laboratory Press; all rights reserved.
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