Role of Polyphosphate in Amyloidogenic Processes.
Journal
Cold Spring Harbor perspectives in biology
ISSN: 1943-0264
Titre abrégé: Cold Spring Harb Perspect Biol
Pays: United States
ID NLM: 101513680
Informations de publication
Date de publication:
01 05 2019
01 05 2019
Historique:
pubmed:
9
1
2019
medline:
25
8
2020
entrez:
9
1
2019
Statut:
epublish
Résumé
Polyphosphate (polyP), an extremely simple polyanion, has long been known to be involved in a variety of different cellular processes, ranging from stress resistance, biofilm formation, and virulence in bacteria to bone mineralization, blood clotting, and mammalian target of rapamycin (mTOR) signaling in mammalian organisms. Our laboratory recently discovered a completely unexpected role of polyP as a stabilizing scaffold for β-sheet-containing protein-folding intermediates. This realization led us to investigate the effects of polyP on amyloidogenic processes and the novel concept that polyP might play a role in neurodegenerative diseases. In this review, we will summarize recent results that show that polyP is a physiological modifier that accelerates amyloid fiber formation, alters fiber morphology, and protects cells against amyloid toxicity. We will review the current knowledge on the distribution, levels, and roles of polyP in the mammalian brain, and discuss potential mechanisms by which polyP might ameliorate amyloid toxicity.
Identifiants
pubmed: 30617049
pii: cshperspect.a034041
doi: 10.1101/cshperspect.a034041
pmc: PMC6496346
mid: NIHMS1062112
pii:
doi:
Substances chimiques
Amyloid
0
Polyphosphates
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM065318
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM116582
Pays : United States
Organisme : NIA NIH HHS
ID : R21 AG055090
Pays : United States
Organisme : NIGMS NIH HHS
ID : R35 GM122506
Pays : United States
Informations de copyright
Copyright © 2019 Cold Spring Harbor Laboratory Press; all rights reserved.
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