AWZ1066S, a highly specific anti-
anti-Wolbachia
drug discovery
lymphatic filariasis
macrofilaricide
onchocerciasis
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
22 01 2019
22 01 2019
Historique:
pubmed:
9
1
2019
medline:
26
3
2019
entrez:
9
1
2019
Statut:
ppublish
Résumé
Onchocerciasis and lymphatic filariasis are two neglected tropical diseases that together affect ∼157 million people and inflict severe disability. Both diseases are caused by parasitic filarial nematodes with elimination efforts constrained by the lack of a safe drug that can kill the adult filaria (macrofilaricide). Previous proof-of-concept human trials have demonstrated that depleting >90% of the essential nematode endosymbiont bacterium,
Identifiants
pubmed: 30617067
pii: 1816585116
doi: 10.1073/pnas.1816585116
pmc: PMC6347715
doi:
Substances chimiques
Anti-Bacterial Agents
0
Pyrimidines
0
Quinazolines
0
thienopyrimidine
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1414-1419Subventions
Organisme : Medical Research Council
ID : MC_PC_16052
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17167
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/R025401/1
Pays : United Kingdom
Informations de copyright
Copyright © 2019 the Author(s). Published by PNAS.
Déclaration de conflit d'intérêts
Conflict of interest statement: An international patent (WO2018134685) that includes chemical compounds described in this manuscript has been filed by the authors (W.D.H., F.B., M.J.T., P.M.O., and S.A.W.). Some authors (F.B., A. Siu, M.S., and F.G.) of this manuscript are full-time employees of Eisai, Inc.
Références
Parasit Vectors. 2014 Oct 24;7:472
pubmed: 25338621
Trop Med Int Health. 2007 Dec;12(12):1433-41
pubmed: 18076549
Clin Infect Dis. 2006 Apr 15;42(8):1081-9
pubmed: 16575724
Sci Rep. 2016 Mar 21;6:23458
pubmed: 26996237
Parasit Vectors. 2012 Mar 20;5:53
pubmed: 22433114
Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9712-E9721
pubmed: 29078351
Lab Anim (NY). 2010 May;39(5):143-8
pubmed: 20410898
Adv Parasitol. 2005;60:245-84
pubmed: 16230105
J Parasitol Res. 2011;2011:201617
pubmed: 21687646
J Med Chem. 2014 Jul 24;57(14):6060-82
pubmed: 24959892
Lancet. 2010 Oct 2;376(9747):1175-85
pubmed: 20739055
Trends Parasitol. 2012 Jan;28(1):16-22
pubmed: 22079526
Nat Rev Drug Discov. 2012 Dec;11(12):909-22
pubmed: 23197038
Ther Drug Monit. 2012 Aug;34(4):467-76
pubmed: 22722776
PLoS Negl Trop Dis. 2010 Apr 13;4(4):e660
pubmed: 20405054
Exp Parasitol. 2009 Sep;123(1):95-8
pubmed: 19463816
J Biomol Screen. 2015 Jan;20(1):64-9
pubmed: 25278497
Sci Rep. 2017 Mar 16;7(1):210
pubmed: 28303006
Curr Opin Infect Dis. 2010 Dec;23(6):617-20
pubmed: 20847694
Sci Rep. 2016 Dec 22;6:39648
pubmed: 28004792
Lancet. 2005 Jun 18-24;365(9477):2116-21
pubmed: 15964448
Med Microbiol Immunol. 2008 Sep;197(3):295-311
pubmed: 17999080
J Biomol Screen. 2014 Mar;19(3):335-43
pubmed: 24241712
J Med Chem. 2016 Oct 27;59(20):9457-9472
pubmed: 27690432
J Infect Dis. 2012 Jul 15;206(2):249-57
pubmed: 22586066
Int Health. 2018 Mar 1;10(suppl_1):i40-i48
pubmed: 29471342
Sci Adv. 2017 Sep 27;3(9):eaao1551
pubmed: 28959730
Int J Parasitol Drugs Drug Resist. 2014 Sep 16;4(3):278-86
pubmed: 25516838
Clin Infect Dis. 2015 Apr 15;60(8):1199-207
pubmed: 25537873
Mol Biochem Parasitol. 2004 May;135(1):57-67
pubmed: 15287587