Genome-wide meta-analysis identifies new loci and functional pathways influencing Alzheimer's disease risk.
Journal
Nature genetics
ISSN: 1546-1718
Titre abrégé: Nat Genet
Pays: United States
ID NLM: 9216904
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
01
03
2018
accepted:
09
11
2018
pubmed:
9
1
2019
medline:
25
4
2019
entrez:
9
1
2019
Statut:
ppublish
Résumé
Alzheimer's disease (AD) is highly heritable and recent studies have identified over 20 disease-associated genomic loci. Yet these only explain a small proportion of the genetic variance, indicating that undiscovered loci remain. Here, we performed a large genome-wide association study of clinically diagnosed AD and AD-by-proxy (71,880 cases, 383,378 controls). AD-by-proxy, based on parental diagnoses, showed strong genetic correlation with AD (r
Identifiants
pubmed: 30617256
doi: 10.1038/s41588-018-0311-9
pii: 10.1038/s41588-018-0311-9
pmc: PMC6836675
mid: NIHMS1031924
doi:
Types de publication
Journal Article
Meta-Analysis
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
404-413Subventions
Organisme : Medical Research Council
ID : MC_PC_17228
Pays : United Kingdom
Organisme : NIGMS NIH HHS
ID : T32 GM080178
Pays : United States
Organisme : Medical Research Council
ID : MR/P021573/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_PC_17214
Pays : United Kingdom
Organisme : NIA NIH HHS
ID : R01 AG059716
Pays : United States
Organisme : EPA
ID : EP-C-14-005
Pays : United States
Organisme : NIA NIH HHS
ID : K01 AG049164
Pays : United States
Organisme : Medical Research Council
ID : MC_QA137853
Pays : United Kingdom
Organisme : NIMH NIH HHS
ID : U01 MH109536
Pays : United States
Organisme : Alzheimer's Society
ID : 171
Pays : United Kingdom
Commentaires et corrections
Type : ErratumIn
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