Severe fever with thrombocytopenia syndrome phlebovirus non-structural protein activates TPL2 signalling pathway for viral immunopathogenesis.
Adaptor Proteins, Signal Transducing
Animals
Bunyaviridae Infections
/ immunology
Female
HEK293 Cells
HeLa Cells
Host-Pathogen Interactions
Humans
Interleukin-10
/ administration & dosage
MAP Kinase Kinase Kinases
/ immunology
Male
Mice
Mice, 129 Strain
Mice, Inbred BALB C
Mice, Inbred C57BL
Mice, Knockout
Phlebovirus
/ drug effects
Proto-Oncogene Proteins
/ immunology
RAW 264.7 Cells
Reverse Genetics
Signal Transduction
Viral Nonstructural Proteins
/ genetics
Journal
Nature microbiology
ISSN: 2058-5276
Titre abrégé: Nat Microbiol
Pays: England
ID NLM: 101674869
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
13
09
2018
accepted:
23
11
2018
pubmed:
9
1
2019
medline:
6
6
2019
entrez:
9
1
2019
Statut:
ppublish
Résumé
Severe fever with thrombocytopenia syndrome phlebovirus (SFTSV), listed in the World Health Organization Prioritized Pathogens, is an emerging phlebovirus with a high fatality
Identifiants
pubmed: 30617349
doi: 10.1038/s41564-018-0329-x
pii: 10.1038/s41564-018-0329-x
pmc: PMC6548314
mid: NIHMS1022675
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Proto-Oncogene Proteins
0
Tnip2 protein, mouse
0
Viral Nonstructural Proteins
0
Interleukin-10
130068-27-8
MAP Kinase Kinase Kinases
EC 2.7.11.25
Map3k8 protein, mouse
EC 2.7.11.25
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
429-437Subventions
Organisme : NIAID NIH HHS
ID : R21 AI129496
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI116585
Pays : United States
Organisme : NIDCR NIH HHS
ID : R21 DE027888
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI140718
Pays : United States
Organisme : Wellcome Trust
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI140705
Pays : United States
Organisme : NIDCR NIH HHS
ID : R01 DE023926
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA180779
Pays : United States
Organisme : Medical Research Council
ID : MC_UU_12014/8
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : R01 AI073099
Pays : United States
Organisme : NCI NIH HHS
ID : R35 CA200422
Pays : United States
Organisme : Wellcome Trust
ID : 210462/Z/18/Z
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
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