Serum lipids in adults with late age-related macular degeneration: a case-control study.
Aged
Aged, 80 and over
C-Reactive Protein
/ metabolism
Case-Control Studies
Cholesterol, HDL
/ blood
Cholesterol, LDL
/ blood
Female
Geographic Atrophy
/ blood
Humans
Lysophosphatidylcholines
/ blood
Macular Degeneration
/ blood
Male
Retinal Neovascularization
/ blood
Risk Factors
Severity of Illness Index
Age-related macular degeneration
Aging
Geographic atrophy
Lipids
Mass spectrometry
Neovascular AMD
Journal
Lipids in health and disease
ISSN: 1476-511X
Titre abrégé: Lipids Health Dis
Pays: England
ID NLM: 101147696
Informations de publication
Date de publication:
08 Jan 2019
08 Jan 2019
Historique:
received:
05
12
2018
accepted:
20
12
2018
entrez:
10
1
2019
pubmed:
10
1
2019
medline:
19
3
2019
Statut:
epublish
Résumé
Lipids are implicated in the pathogenesis of age-related macular degeneration (AMD). The relationship between systemic lipids and AMD has not been well characterized. The objective was to investigate the relationship between serum lipids and AMD in older adults using a lipidomic approach. In a case-control study, 240 adults, aged ≥66 years, a third each having geographic atrophy, neovascular AMD, or no signs of AMD, were selected from a population-based sample of participants in the Age Gene/Environment Susceptibility-Reykjavik Study. The exposure was serum lipids and risk factors for AMD. The outcome was late AMD, assessed through fundus images taken through dilated pupils using a 45-degree digital camera and grading for neovascular AMD and geographic atrophy using the modified Wisconsin Age-Related Maculopathy Grading System. Of 177 serum lipid species measured, there were no significant differences in serum lipids between controls and those with geographic atrophy or neovascular AMD, respectively. Adults with neovascular AMD had higher total serum lysophosphatidylcholine (LPC) (P = 0.004) and serum LPC 18:0 (P = 0.0002) compared to those with geographic atrophy. Late AMD was not characterized by alterations in systemic lipids compared with normal controls. These findings suggest that there may be differences in the LPC pathway between adults with neovascular AMD and geographic atrophy.
Sections du résumé
BACKGROUND
BACKGROUND
Lipids are implicated in the pathogenesis of age-related macular degeneration (AMD). The relationship between systemic lipids and AMD has not been well characterized. The objective was to investigate the relationship between serum lipids and AMD in older adults using a lipidomic approach.
METHODS
METHODS
In a case-control study, 240 adults, aged ≥66 years, a third each having geographic atrophy, neovascular AMD, or no signs of AMD, were selected from a population-based sample of participants in the Age Gene/Environment Susceptibility-Reykjavik Study. The exposure was serum lipids and risk factors for AMD. The outcome was late AMD, assessed through fundus images taken through dilated pupils using a 45-degree digital camera and grading for neovascular AMD and geographic atrophy using the modified Wisconsin Age-Related Maculopathy Grading System.
RESULTS
RESULTS
Of 177 serum lipid species measured, there were no significant differences in serum lipids between controls and those with geographic atrophy or neovascular AMD, respectively. Adults with neovascular AMD had higher total serum lysophosphatidylcholine (LPC) (P = 0.004) and serum LPC 18:0 (P = 0.0002) compared to those with geographic atrophy.
CONCLUSION
CONCLUSIONS
Late AMD was not characterized by alterations in systemic lipids compared with normal controls. These findings suggest that there may be differences in the LPC pathway between adults with neovascular AMD and geographic atrophy.
Identifiants
pubmed: 30621701
doi: 10.1186/s12944-018-0954-7
pii: 10.1186/s12944-018-0954-7
pmc: PMC6323843
doi:
Substances chimiques
Cholesterol, HDL
0
Cholesterol, LDL
0
Lysophosphatidylcholines
0
C-Reactive Protein
9007-41-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
7Subventions
Organisme : National Institutes of Health
ID : R01 AG027012
Organisme : National Institutes of Health
ID : R01 EY017362
Organisme : National Institutes of Health
ID : ZIAEY00401
Organisme : National Institutes of Health
ID : N01-AG-1-2100
Organisme : National Institutes of Health
ID : HHSN27120120022C
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