Polysomnography Findings and Sleep Disorders in Children With Alternating Hemiplegia of Childhood.
alternating hemiplegia of childhood
behavioral insomnia
central sleep apnea
obstructive sleep apnea
sleep-disordered breathing
Journal
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine
ISSN: 1550-9397
Titre abrégé: J Clin Sleep Med
Pays: United States
ID NLM: 101231977
Informations de publication
Date de publication:
15 01 2019
15 01 2019
Historique:
received:
14
06
2018
accepted:
06
09
2018
pubmed:
10
1
2019
medline:
14
4
2020
entrez:
10
1
2019
Statut:
epublish
Résumé
Patients with alternating hemiplegia of childhood (AHC) experience bouts of hemiplegia and other paroxysmal spells that resolve during sleep. Patients often have multiple comorbidities that could negatively affect sleep, yet sleep quality and sleep pathology in AHC are not well characterized. This study aimed to report sleep data from both polysomnography (PSG) and clinical evaluations in children with AHC. We analyzed nocturnal PSG and clinical sleep evaluation results of a cohort of 22 consecutive pediatric patients with AHC who were seen in our AHC multidisciplinary clinic and who underwent evaluations according to our comprehensive AHC clinical pathway. This pathway includes, regardless of presenting symptoms, baseline PSG and evaluation by a board-certified pediatric sleep specialist. Out of 22 patients, 20 had at least one type of sleep problem. Six had obstructive sleep apnea as documented on polysomnogram, of whom two had no prior report of sleep-disordered breathing symptoms. Patients had abnormal mean overall apnea-hypopnea index of 5.8 (range 0-38.7) events/h and an abnormal mean arousal index of 15.0 (range 4.8-46.6) events/h. Based on sleep history, 16 patients had difficulty falling asleep, staying asleep, or both; 9 had behavioral insomnia of childhood; and 2 had delayed sleep-wake phase syndrome. Sleep dysfunction is common among children with AHC. Physicians should routinely screen for sleep pathology, with a low threshold to obtain a nocturnal PSG.
Identifiants
pubmed: 30621840
doi: 10.5664/jcsm.7572
pii: jc-18-00366
pmc: PMC6329557
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
65-70Informations de copyright
© 2019 American Academy of Sleep Medicine.
Références
Eur J Med Genet. 2014 Jan;57(1):37-9
pubmed: 24291144
Brain Res. 2017 Jul 1;1666:27-37
pubmed: 28465228
Pediatr Neurol. 2000 Aug;23(2):134-41
pubmed: 11020638
Pediatr Pulmonol. 2007 Feb;42(2):159-67
pubmed: 17186545
Cell Mol Neurobiol. 2014 Aug;34(6):777-89
pubmed: 24798513
J Pediatr. 1993 May;122(5 Pt 1):673-9
pubmed: 8496742
Handb Clin Neurol. 2013;112:821-6
pubmed: 23622289
J Child Neurol. 2003 Nov;18(11):763-6
pubmed: 14696903
Pediatrics. 1971 Apr;47(4):675-80
pubmed: 5089756
Orphanet J Rare Dis. 2015 Sep 26;10:123
pubmed: 26410222
Neuron. 2013 Jun 5;78(5):799-806
pubmed: 23764285
Respir Physiol. 2000 Feb;119(2-3):143-54
pubmed: 10722857
Curr Treat Options Neurol. 2017 Feb;19(2):8
pubmed: 28337648
Arch Neurol. 2000 Mar;57(3):363-8
pubmed: 10714662
Neurobiol Dis. 2018 Nov;119:100-112
pubmed: 30071271
Epilepsia. 2015 Jan;56(1):82-93
pubmed: 25523819
Continuum (Minneap Minn). 2017 Aug;23(4, Sleep Neurology):1117-1131
pubmed: 28777179
Epilepsia. 2018 Jul;59(7):1455-1468
pubmed: 29889309
Sleep Breath. 2015 May;19(2):421-32
pubmed: 25404374
Brain. 2015 Oct;138(Pt 10):2859-74
pubmed: 26297560
J R Soc Med. 2001 Apr;94(4):177-9
pubmed: 11317619
Prim Care. 2008 Sep;35(3):533-46, vii
pubmed: 18710669
Nat Genet. 2012 Sep;44(9):1030-4
pubmed: 22842232
Respir Physiol Neurobiol. 2016 Apr;224:17-26
pubmed: 25220696
Semin Neurol. 2004 Sep;24(3):301-13
pubmed: 15449223
Neurology. 2000 Oct 10;55(7):1002-7
pubmed: 11061259
Lancet Neurol. 2014 May;13(5):503-14
pubmed: 24739246
Sleep. 2006 Sep;29(9):1115-34
pubmed: 17040000
J Neurosci. 2008 Apr 30;28(18):4649-60
pubmed: 18448642
Brain. 2010 Dec;133(Pt 12):3598-610
pubmed: 20974617
Dev Med Child Neurol. 2019 May;61(5):547-554
pubmed: 30362107
Dev Med Child Neurol. 2017 Aug;59(8):822-828
pubmed: 28543714
J Comp Neurol. 2011 Feb 1;519(2):376-404
pubmed: 21165980
Am J Respir Crit Care Med. 2003 Dec 15;168(12):1540
pubmed: 14668259
Respir Physiol Neurobiol. 2008 Dec 10;164(1-2):179-96
pubmed: 18620080