MIPSS70+ v2.0 predicts long-term survival in myelofibrosis after allogeneic HCT with the Flu/Mel conditioning regimen.
Adult
Aged
Female
Graft vs Host Disease
/ etiology
Hematopoietic Stem Cell Transplantation
/ adverse effects
Humans
Kaplan-Meier Estimate
Male
Melphalan
/ administration & dosage
Middle Aged
Mutation
Primary Myelofibrosis
/ diagnosis
Prognosis
Transplantation Conditioning
Transplantation, Homologous
Treatment Outcome
Unrelated Donors
Vidarabine Phosphate
/ administration & dosage
Journal
Blood advances
ISSN: 2473-9537
Titre abrégé: Blood Adv
Pays: United States
ID NLM: 101698425
Informations de publication
Date de publication:
08 01 2019
08 01 2019
Historique:
received:
27
09
2018
accepted:
07
12
2018
entrez:
10
1
2019
pubmed:
10
1
2019
medline:
10
1
2020
Statut:
ppublish
Résumé
Although allogeneic hematopoietic cell transplantation (allo-HCT) is the only curative treatment for myelofibrosis (MF), data are limited on how molecular markers predict transplantation outcomes. We retrospectively evaluated transplantation outcomes of 110 consecutive MF patients who underwent allo-HCT with a fludarabine/melphalan (Flu/Mel) conditioning regimen at our center and assessed the impact of molecular markers on outcomes based on a 72-gene next-generation sequencing panel and Mutation-Enhanced International Prognostic Scoring System 70+ v2.0 (MIPSS70+ v2.0). With a median follow-up of 63.7 months, the 5-year overall survival (OS) rate was 65% and the nonrelapse mortality (NRM) rate was 17%. In mutational analysis, JAK2 V617F and ASXL1 mutations were the most common. By univariable analysis, higher Dynamic International Prognostic Scoring System scores, unrelated donor type, and very-high-risk cytogenetics were significantly associated with lower OS. Only CBL mutations were significantly associated with lower OS (hazard ratio [HR], 2.64;
Identifiants
pubmed: 30622146
pii: bloodadvances.2018026658
doi: 10.1182/bloodadvances.2018026658
pmc: PMC6325305
doi:
Substances chimiques
Vidarabine Phosphate
106XV160TZ
fludarabine phosphate
1X9VK9O1SC
Melphalan
Q41OR9510P
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
83-95Subventions
Organisme : NCI NIH HHS
ID : P30 CA033572
Pays : United States
Informations de copyright
© 2019 by The American Society of Hematology.
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