To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps.
Journal
Cell death and differentiation
ISSN: 1476-5403
Titre abrégé: Cell Death Differ
Pays: England
ID NLM: 9437445
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
18
05
2018
accepted:
30
11
2018
revised:
05
11
2018
pubmed:
10
1
2019
medline:
4
6
2020
entrez:
10
1
2019
Statut:
ppublish
Résumé
Since the discovery and definition of neutrophil extracellular traps (NETs) 14 years ago, numerous characteristics and physiological functions of NETs have been uncovered. Nowadays, the field continues to expand and novel mechanisms that orchestrate formation of NETs, their previously unknown properties, and novel implications in disease continue to emerge. The abundance of available data has also led to some confusion in the NET research community due to contradictory results and divergent scientific concepts, such as pro- and anti-inflammatory roles in pathologic conditions, demarcation from other forms of cell death, or the origin of the DNA that forms the NET scaffold. Here, we present prevailing concepts and state of the science in NET-related research and elaborate on open questions and areas of dispute.
Identifiants
pubmed: 30622307
doi: 10.1038/s41418-018-0261-x
pii: 10.1038/s41418-018-0261-x
pmc: PMC6370810
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
395-408Subventions
Organisme : NIAMS NIH HHS
ID : R01 AR069569
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL134846
Pays : United States
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