Importance of the commissural nucleus of the solitary tract in renovascular hypertension.
AT1 subtype receptor
angiotensin II
commissural NTS
renal hypertension
Journal
Hypertension research : official journal of the Japanese Society of Hypertension
ISSN: 1348-4214
Titre abrégé: Hypertens Res
Pays: England
ID NLM: 9307690
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
06
06
2018
accepted:
09
10
2018
revised:
05
10
2018
pubmed:
10
1
2019
medline:
15
9
2020
entrez:
10
1
2019
Statut:
ppublish
Résumé
The rodent renovascular hypertension model has been used to investigate the mechanisms promoting hypertension. The importance of the carotid body for renovascular hypertension has been demonstrated. As the commissural NTS (cNTS) is the first synaptic site in the central nervous system that receives information from carotid body chemoreceptors, we evaluated the contribution of cNTS to renovascular hypertension in the present study. Normotensive male Holtzman rats were implanted with a silver clip around the left renal artery to induce two-kidney, one-clip (2K1C) hypertension. Six weeks later, isoguvacine (a GABA
Identifiants
pubmed: 30622315
doi: 10.1038/s41440-018-0190-6
pii: 10.1038/s41440-018-0190-6
doi:
Substances chimiques
Angiotensin II Type 1 Receptor Blockers
0
Types de publication
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
587-597Commentaires et corrections
Type : CommentIn