Stem cell replication, somatic mutations and role of randomness in the development of cancer.
Cancer
Environment
Epidemiology
Risk factors
Somatic mutations
Journal
European journal of epidemiology
ISSN: 1573-7284
Titre abrégé: Eur J Epidemiol
Pays: Netherlands
ID NLM: 8508062
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
13
07
2018
accepted:
17
12
2018
pubmed:
10
1
2019
medline:
21
9
2019
entrez:
10
1
2019
Statut:
ppublish
Résumé
An intense scientific debate has recently taken place relating to the "bad luck" hypothesis in cancer development, namely that intrinsic random, and therefore unavoidable, mutagenic events would have a predominant role in tumorigenesis. In this article we review the main contributions to this debate and explain the reasons why the claim that cancer is mostly explained by intrinsic random factors is unsupported by data and theoretical models. In support of this, we present an analysis showing that smoking-induced mutations are more predictive of cancer risk than the lifetime number of stem cell cellular divisions.
Identifiants
pubmed: 30623292
doi: 10.1007/s10654-018-0477-6
pii: 10.1007/s10654-018-0477-6
pmc: PMC10654895
mid: NIHMS1942254
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
439-445Subventions
Organisme : Medical Research Council
ID : MR/L01341X/1
Pays : United Kingdom
Organisme : Intramural NIH HHS
ID : Z99 CA999999
Pays : United States
Commentaires et corrections
Type : CommentIn
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