No evidence so far of a major role of AKT1 and GSK3B in the pathogenesis of antipsychotic-induced tardive dyskinesia.

Adult Antipsychotic Agents / adverse effects Female Glycogen Synthase Kinase 3 beta / genetics Humans Male Middle Aged Polymorphism, Single Nucleotide Proto-Oncogene Proteins c-akt / genetics Receptors, Dopamine D2 / physiology Tardive Dyskinesia / chemically induced
AKT1 GSK3B antipsychotics pharmacogenetics schizophrenia tardive dyskinesia

Journal

Human psychopharmacology
ISSN: 1099-1077
Titre abrégé: Hum Psychopharmacol
Pays: England
ID NLM: 8702539

Informations de publication

Date de publication:
01 2019
Historique:
received: 28 06 2018
revised: 11 12 2018
accepted: 12 12 2018
pubmed: 10 1 2019
medline: 13 3 2020
entrez: 10 1 2019
Statut: ppublish

Résumé

AKT1 and GSK3B take part in one of the intracellular cascades activated by the D2 dopamine receptor (DRD2). This receptor is antagonized by antipsychotics and plays a role in the pathogenesis of antipsychotic-induced tardive dyskinesia (TD). The present study investigated association of several polymorphisms in the two candidate genes, AKT1 and GSK3B, with TD in antipsychotic-treated patients with schizophrenia. DNA samples from 449 patients from several Siberian regions (Russia) were genotyped, and the results were analyzed using chi-squared tests and analyses of variance. Antipsychotic-induced TD was not associated with either of the tested functional polymorphisms (rs334558, rs1130214, and rs3730358). Despite regulation of AKT1 and GSK3B by DRD2, we found no evidence that these two kinases play a major role in the pathogenesis of antipsychotic-induced TD. These results agree with previously published data and necessitate further exploration of other pathogenic mechanisms, such as neurotoxicity due to excessive dopamine metabolism.

Identifiants

DOI: 10.1002/hup.2685 PMID: 30623492
pubmed: 30623492
doi: 10.1002/hup.2685
doi:

Substances chimiques

Antipsychotic Agents 0
Receptors, Dopamine D2 0
AKT1 protein, human EC 2.7.11.1
GSK3B protein, human EC 2.7.11.1
Glycogen Synthase Kinase 3 beta EC 2.7.11.1
Proto-Oncogene Proteins c-akt EC 2.7.11.1

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2685

Subventions

Organisme : Siberian Branch, Russian Academy of Sciences
ID : 30
Pays : International

Informations de copyright

© 2019 John Wiley & Sons, Ltd.

Auteurs

Anastasia Levchenko (A)

Institute of Translational Biomedicine, Saint Petersburg State University, Saint Petersburg, Russia.
ORCID: 0000-0003-3509-1304

Natalya Vyalova (N)

Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute, Tomsk, Russia.

Ivan V Pozhidaev (IV)

Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute, Tomsk, Russia.

Anastasiia S Boiko (AS)

Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute, Tomsk, Russia.

Diana Z Osmanova (DZ)

Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute, Tomsk, Russia.

Olga Yu Fedorenko (OY)

Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute, Tomsk, Russia.
Division for Control and Diagnostics, School of Non-Destructive Testing & Security, National Research Tomsk Polytechnic University, Tomsk, Russia.

Arkadiy V Semke (AV)

Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute, Tomsk, Russia.

Nikolay A Bokhan (NA)

Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute, Tomsk, Russia.
Department of Psychotherapy and Psychological Counseling, National Research Tomsk State University, Tomsk, Russia.

Bob Wilffert (B)

Unit of PharmacoTherapy, Epidemiology and Economics, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands.
Department of Clinical Pharmacy and Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

Anton J M Loonen (AJM)

Unit of PharmacoTherapy, Epidemiology and Economics, Groningen Research Institute of Pharmacy, University of Groningen, Groningen, The Netherlands.
GGZ Westelijk Noord-Brabant, Bergen op Zoom, The Netherlands.

Svetlana A Ivanova (SA)

Tomsk National Research Medical Center of the Russian Academy of Sciences, Mental Health Research Institute, Tomsk, Russia.
Division for Control and Diagnostics, School of Non-Destructive Testing & Security, National Research Tomsk Polytechnic University, Tomsk, Russia.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › No evidence so far of a major role of AKT1 and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Agents du système nerveux central › Psychoanaleptiques › Tranquillisants › Neuroleptiques › No evidence so far of a major role of AKT1 and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-Serine-Threonine Kinases › Proline-directed protein kinases › Glycogen Synthase Kinase 3 › Glycogen synthase kinase 3 beta › No evidence so far of a major role of AKT1 and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › No evidence so far of a major role of AKT1 and...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › No evidence so far of a major role of AKT1 and...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › No evidence so far of a major role of AKT1 and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Protéines oncogènes › Protéines proto-oncogènes › Protéines proto-oncogènes c-akt › No evidence so far of a major role of AKT1 and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs catécholaminergiques › Récepteurs dopaminergiques › Récepteur D2 de la dopamine › No evidence so far of a major role of AKT1 and...
questionsmedicales.fr › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Dyskinésies › Dyskinésie tardive › No evidence so far of a major role of AKT1 and...