Comparative study on the metabolism of the ergot alkaloids ergocristine, ergocryptine, ergotamine, and ergovaline in equine and human S9 fractions and equine liver preparations.
Ergot alkaloids
HRMS/MS
S9 mix
equine
fescue toxicosis
human
liver preparation
metabolism
Journal
Xenobiotica; the fate of foreign compounds in biological systems
ISSN: 1366-5928
Titre abrégé: Xenobiotica
Pays: England
ID NLM: 1306665
Informations de publication
Date de publication:
Oct 2019
Oct 2019
Historique:
pubmed:
10
1
2019
medline:
20
12
2019
entrez:
10
1
2019
Statut:
ppublish
Résumé
1. Ergopeptine alkaloids like ergovaline and ergotamine are suspected to be associated with fescue toxicosis and ergotism in horses. Information on the metabolism of ergot alkaloids is scarce, especially in horses, but needed for toxicological analysis of these drugs in urine/feces of affected horses. The aim of this study was to investigate the metabolism of ergovaline, ergotamine, ergocristine, and ergocryptine in horses and comparison to humans. 2. Supernatants of alkaloid incubations with equine and human liver S9 fractions were analyzed by reversed-phase liquid-chromatography coupled to high-resolution tandem mass spectrometry with full scan and MS
Identifiants
pubmed: 30623698
doi: 10.1080/00498254.2018.1542187
doi:
Substances chimiques
Ergolines
0
Ergotamines
0
ergovaline
059E2O9IV4
ergocristine
3E58HO2T0U
ergocryptine
511-09-1
Ergotamine
PR834Q503T
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM