A safe and efficacious Pt(ii) anticancer prodrug: design, synthesis, in vitro efficacy, the role of carrier ligands and in vivo tumour growth inhibition.
A549 Cells
Animals
Antineoplastic Agents
/ chemistry
Cell Proliferation
/ drug effects
Coordination Complexes
/ chemistry
Crystallography, X-Ray
Drug Design
Humans
Ligands
Liposomes
/ chemistry
Lung Neoplasms
/ drug therapy
Mice
Molecular Conformation
Platinum
/ chemistry
Prodrugs
/ chemistry
Transplantation, Heterologous
Journal
Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838
Informations de publication
Date de publication:
05 Feb 2019
05 Feb 2019
Historique:
pubmed:
10
1
2019
medline:
15
2
2019
entrez:
10
1
2019
Statut:
ppublish
Résumé
Diaminocyclohexane-Pt(ii)-phenalenyl complexes (1 and 2) showed an appropriate balance between efficacy and toxicity. Compound 2 showed nearly two-fold higher tumour growth inhibition than oxaliplatin in a murine NSCLC tumour model, when a combined drug development approach was used. The fluorescent properties of phenalenone were utilized to understand the mechanistic details of the drug.
Substances chimiques
Antineoplastic Agents
0
Coordination Complexes
0
Ligands
0
Liposomes
0
Prodrugs
0
Platinum
49DFR088MY
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM