Diagnosing lanolin contact allergy with lanolin alcohol and Amerchol L101.
Amerchol L-101
cetyl alcohol
contact allergy
lanolin alcohol
patch testing
vehicle
wool alcohols
Journal
Contact dermatitis
ISSN: 1600-0536
Titre abrégé: Contact Dermatitis
Pays: England
ID NLM: 7604950
Informations de publication
Date de publication:
May 2019
May 2019
Historique:
received:
22
08
2018
revised:
31
12
2018
accepted:
04
01
2019
pubmed:
10
1
2019
medline:
11
9
2019
entrez:
10
1
2019
Statut:
ppublish
Résumé
The prevalence of lanolin contact allergy in dermatitis patients varies from 1.2% to 6.9%. Different lanolin derivatives are used in patch testing. To determine which combination of lanolin derivatives is most effective in patch testing for the diagnosis of lanolin contact allergy. A retrospective analysis of patients patch tested between 2016 and 2017 was performed. Patients were eligible if they had been tested with lanolin alcohol 30% pet., Amerchol L101 50% pet., and a supplementary series containing other lanolin derivatives. Lanolin alcohol and Amerchol L101 were tested in duplicate. Of 594 patients, 28.6% (95% confidence interval [CI]: 25.1%-32.3%) had a positive patch test reaction to at least one lanolin derivative. Reactions to lanolin alcohol (14.7%, 95%CI: 11.3%-18.2%) and Amerchol L101 (15.0%, 95%CI: 11.5%-18.5%) were common in the routinely tested series. Reactions to other test preparations were significantly less frequent (P < 0.05). The addition of Amerchol L101 to lanolin alcohol significantly increased the number of positive cases (odds ratio 1.79, P < 0.001). The combination of lanolin alcohol and Amerchol L101 is effective in patch testing for the diagnosis of lanolin contact allergy. Routinely testing with other lanolin derivatives may not be worthwhile, as it detects only a few additional patients.
Sections du résumé
BACKGROUND
BACKGROUND
The prevalence of lanolin contact allergy in dermatitis patients varies from 1.2% to 6.9%. Different lanolin derivatives are used in patch testing.
OBJECTIVES
OBJECTIVE
To determine which combination of lanolin derivatives is most effective in patch testing for the diagnosis of lanolin contact allergy.
METHODS
METHODS
A retrospective analysis of patients patch tested between 2016 and 2017 was performed. Patients were eligible if they had been tested with lanolin alcohol 30% pet., Amerchol L101 50% pet., and a supplementary series containing other lanolin derivatives. Lanolin alcohol and Amerchol L101 were tested in duplicate.
RESULTS
RESULTS
Of 594 patients, 28.6% (95% confidence interval [CI]: 25.1%-32.3%) had a positive patch test reaction to at least one lanolin derivative. Reactions to lanolin alcohol (14.7%, 95%CI: 11.3%-18.2%) and Amerchol L101 (15.0%, 95%CI: 11.5%-18.5%) were common in the routinely tested series. Reactions to other test preparations were significantly less frequent (P < 0.05). The addition of Amerchol L101 to lanolin alcohol significantly increased the number of positive cases (odds ratio 1.79, P < 0.001).
CONCLUSIONS
CONCLUSIONS
The combination of lanolin alcohol and Amerchol L101 is effective in patch testing for the diagnosis of lanolin contact allergy. Routinely testing with other lanolin derivatives may not be worthwhile, as it detects only a few additional patients.
Identifiants
pubmed: 30624788
doi: 10.1111/cod.13210
pmc: PMC6593808
doi:
Substances chimiques
Alcohols
0
Amerchol L101
0
Lanolin
8006-54-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
298-303Informations de copyright
© 2019 The Authors. Contact Dermatitis published by John Wiley & Sons Ltd.
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