Alum adjuvant is more effective than MF59 at prompting early germinal center formation in response to peptide-protein conjugates and enhancing efficacy of a vaccine against opioid use disorders.
Adjuvants, Immunologic
/ administration & dosage
Alum Compounds
/ administration & dosage
Animals
B-Lymphocytes
/ immunology
Drug Overdose
Germinal Center
/ drug effects
Male
Mice
Mice, Inbred BALB C
Mice, Inbred C57BL
Opioid-Related Disorders
/ immunology
Oxycodone
/ chemistry
Peptides
/ chemistry
Polysorbates
/ administration & dosage
Proteins
/ chemistry
Squalene
/ administration & dosage
Vaccines, Conjugate
/ administration & dosage
B cell
T cell
adjuvant
germinal center
opioid use disorder
oxycodone
vaccine
Journal
Human vaccines & immunotherapeutics
ISSN: 2164-554X
Titre abrégé: Hum Vaccin Immunother
Pays: United States
ID NLM: 101572652
Informations de publication
Date de publication:
2019
2019
Historique:
pubmed:
10
1
2019
medline:
29
2
2020
entrez:
10
1
2019
Statut:
ppublish
Résumé
Opioid use disorders (OUD) and fatal overdoses are a national emergency in the United States. Therapeutic vaccines offer a promising strategy to treat OUD and reduce the incidence of overdose. Immunization with opioid-based haptens conjugated to immunogenic carriers elicits opioid-specific antibodies that block opioid distribution to the brain and reduce opioid-induced behavior and toxicity in pre-clinical models. This study tested whether the efficacy of a lead oxycodone conjugate vaccine was improved by formulation in either aluminum hydroxide or the squalene-based oil-in-water emulsion MF59 adjuvant, which was recently FDA-approved for influenza vaccines in subjects 65
Identifiants
pubmed: 30625019
doi: 10.1080/21645515.2018.1558697
pmc: PMC6605845
doi:
Substances chimiques
Adjuvants, Immunologic
0
Alum Compounds
0
MF59 oil emulsion
0
Peptides
0
Polysorbates
0
Proteins
0
Vaccines, Conjugate
0
aluminum sulfate
34S289N54E
Squalene
7QWM220FJH
Oxycodone
CD35PMG570
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
909-917Subventions
Organisme : NIDA NIH HHS
ID : R01 DA041730
Pays : United States
Organisme : NIDA NIH HHS
ID : T32 DA007097
Pays : United States
Organisme : NIDA NIH HHS
ID : U01 DA038876
Pays : United States
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