INSL3 in the muscolo-skeletal system.

Animals Bone and Bones / metabolism Humans Insulin / metabolism Muscles / metabolism Musculoskeletal System / metabolism Proteins / metabolism Receptors, G-Protein-Coupled / metabolism Signal Transduction
Hypogonadism INSL3 Leydig cells Osteoporosis RXFP2 Sarcopenia

Journal

Molecular and cellular endocrinology
ISSN: 1872-8057
Titre abrégé: Mol Cell Endocrinol
Pays: Ireland
ID NLM: 7500844

Informations de publication

Date de publication:
01 05 2019
Historique:
received: 05 11 2018
revised: 27 12 2018
accepted: 31 12 2018
pubmed: 10 1 2019
medline: 16 1 2020
entrez: 10 1 2019
Statut: ppublish

Résumé

Bone and skeletal muscle are currently considered a unified functional unit, showing complementary regulation at mechanical, biochemical, paracrine and metabolic levels. This functional unit undergoes a central hormonal regulation which is mainly ascribed to sex steroids and, in particular, androgens. However, recent evidence suggest that another testicular hormone lines the classical anabolic effect of testosterone on bone and muscle, the insulin-like peptide 3 (INSL3) acting on its specific receptor RXFP2. This minireview focuses on the most recent findings describing the role of INSL3/RXFP2 axis on the muscolo-skeletal system, from the mechanistic insights to the phenotypic consequences. Pathophysiological and therapeutic widenings deriving from available data are also discussed.

Identifiants

DOI: 10.1016/j.mce.2018.12.021 PMID: 30625346
pubmed: 30625346
pii: S0303-7207(18)30382-4
doi: 10.1016/j.mce.2018.12.021
pii:
doi:

Substances chimiques

Insulin 0
Leydig insulin-like protein 0
Proteins 0
Receptors, G-Protein-Coupled 0

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

12-17

Informations de copyright

Copyright © 2019 Elsevier B.V. All rights reserved.

Auteurs

Luca De Toni (L)

Department of Medicine, University of Padova, Via Giustiniani 2, 35121, Padova, Italy. Electronic address: detoni.luca@gmail.com.

Alexander I Agoulnik (AI)

Department of Human and Molecular Genetics, Herbert Wertheim College of Medicine, Florida International University, 11200 SW 8th Street, 33199, Miami, FL, USA. Electronic address: aagoulni@fiu.edu.

Marco Sandri (M)

Department of Biomedical Sciences, University of Padova, Via Colombo 3, 35100, Padova, Italy; Venetian Institute of Molecular Medicine, Via Orus 2, 35129, Padova, Italy. Electronic address: marco.sandri@unipd.it.

Carlo Foresta (C)

Department of Medicine, University of Padova, Via Giustiniani 2, 35121, Padova, Italy. Electronic address: carlo.foresta@unipd.it.

Alberto Ferlin (A)

Unit of Endocrinology, Department of Clinical and Experimental Sciences, University of Brescia, Viale Europa 11, 25123, Brescia, Italy. Electronic address: alberto.ferlin@unibs.it.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female

Evaluation of Low-Value Services Across Major Medicare Advantage Insurers and Traditional Medicare.

Ciara Duggan, Adam L Beckman, Ishani Ganguli et al.
1.00
Humans United States Aged Cross-Sectional Studies Medicare Part C

Effectiveness of Virtual Yoga for Chronic Low Back Pain: A Randomized Clinical Trial.

Hallie Tankha, Devyn Gaskins, Amanda Shallcross et al.
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › INSL3 in the muscolo-skeletal system.
questionsmedicales.fr › Tissus › Tissu conjonctif › Os et tissu osseux › INSL3 in the muscolo-skeletal system.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › INSL3 in the muscolo-skeletal system.
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Hormones peptidiques › Hormones pancréatiques › Insulines › Insuline › INSL3 in the muscolo-skeletal system.
questionsmedicales.fr › Tissus › Muscles › INSL3 in the muscolo-skeletal system.
questionsmedicales.fr › Appareil locomoteur › INSL3 in the muscolo-skeletal system.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › INSL3 in the muscolo-skeletal system.
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › INSL3 in the muscolo-skeletal system.
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › INSL3 in the muscolo-skeletal system.