Mechanisms of compensatory plasticity for respiratory motor neuron death.
Breathing
Compensatory plasticity
Diaphragm
Motor unit
Neuromotor control
Plasticity
Respiratory control
Ventilatory behaviors
Journal
Respiratory physiology & neurobiology
ISSN: 1878-1519
Titre abrégé: Respir Physiol Neurobiol
Pays: Netherlands
ID NLM: 101140022
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
21
09
2018
revised:
22
12
2018
accepted:
03
01
2019
pubmed:
10
1
2019
medline:
3
4
2020
entrez:
10
1
2019
Statut:
ppublish
Résumé
Respiratory motor neuron death arises from multiple neurodegenerative and traumatic neuromuscular disorders. Despite motor neuron death, compensatory mechanisms minimize its functional impact by harnessing intrinsic mechanisms of compensatory respiratory plasticity. However, the capacity for compensation eventually reaches limits and pathology ensues. Initially, challenges to the system such as increased metabolic demand reveal sub-clinical pathology. With greater motor neuron loss, the eventual result is de-compensation, ventilatory failure, ventilator dependence and then death. In this brief review, we discuss recent advances in our understanding of mechanisms giving rise to compensatory respiratory plasticity in response to respiratory motor neuron death including: 1) increased central respiratory drive, 2) plasticity in synapses on spared phrenic motor neurons, 3) enhanced neuromuscular transmission and 4) shifts in respiratory muscle utilization from more affected to less affected motor pools. Some of these compensatory mechanisms may prolong breathing function, but hasten the demise of surviving motor neurons. Improved understanding of these mechanisms and their impact on survival of spared motor neurons will guide future efforts to develop therapeutic interventions that preserve respiratory function with neuromuscular injury/disease.
Identifiants
pubmed: 30625378
pii: S1569-9048(18)30301-X
doi: 10.1016/j.resp.2019.01.001
pmc: PMC6579668
mid: NIHMS1518453
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
32-39Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL069064
Pays : United States
Organisme : NHLBI NIH HHS
ID : R37 HL069064
Pays : United States
Informations de copyright
Copyright © 2019 Elsevier B.V. All rights reserved.
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