Association Between Residual Inhibition and Neural Activity in Patients with Tinnitus: Protocol for a Controlled Within- and Between-Subject Comparison Study.
electroencephalography
heterogeneity
high-frequency audiometry
neural activity
tinnitometry
tinnitus
Journal
JMIR research protocols
ISSN: 1929-0748
Titre abrégé: JMIR Res Protoc
Pays: Canada
ID NLM: 101599504
Informations de publication
Date de publication:
09 Jan 2019
09 Jan 2019
Historique:
received:
22
09
2018
accepted:
25
10
2018
revised:
25
10
2018
entrez:
11
1
2019
pubmed:
11
1
2019
medline:
11
1
2019
Statut:
epublish
Résumé
Electroencephalography (EEG) studies indicate possible associations between tinnitus and changes in the neural activity. However, inconsistent results require further investigation to better understand such heterogeneity and inform the interpretation of previous findings. This study aims to investigate the feasibility of EEG measurements as an objective indicator for the identification of tinnitus-associated neural activities. To reduce heterogeneity, participants served as their own control using residual inhibition (RI) to modulate the tinnitus perception in a within-subject EEG study design with a tinnitus group. In addition, comparison with a nontinnitus control group allowed for a between-subjects comparison. We will apply RI stimulation to generate tinnitus and nontinnitus conditions in the same subject. Furthermore, high-frequency audiometry (up to 13 kHz) and tinnitometry will be performed. This work was funded by the Infrastructure Grant of the University of Bern, Bern, Switzerland and Bernafon AG, Bern, Switzerland. Enrollment for the study described in this protocol commenced in February 2018. Data analysis is currently under way and the first results are expected to be submitted for publication in 2019. This study design helps in comparing the neural activity between conditions in the same individual, thereby addressing a notable limitation of previous EEG tinnitus studies. In addition, the high-frequency assessment will help to analyze and classify tinnitus symptoms beyond the conventional clinical standard. RR1-10.2196/12270.
Sections du résumé
BACKGROUND
BACKGROUND
Electroencephalography (EEG) studies indicate possible associations between tinnitus and changes in the neural activity. However, inconsistent results require further investigation to better understand such heterogeneity and inform the interpretation of previous findings.
OBJECTIVE
OBJECTIVE
This study aims to investigate the feasibility of EEG measurements as an objective indicator for the identification of tinnitus-associated neural activities.
METHODS
METHODS
To reduce heterogeneity, participants served as their own control using residual inhibition (RI) to modulate the tinnitus perception in a within-subject EEG study design with a tinnitus group. In addition, comparison with a nontinnitus control group allowed for a between-subjects comparison. We will apply RI stimulation to generate tinnitus and nontinnitus conditions in the same subject. Furthermore, high-frequency audiometry (up to 13 kHz) and tinnitometry will be performed.
RESULTS
RESULTS
This work was funded by the Infrastructure Grant of the University of Bern, Bern, Switzerland and Bernafon AG, Bern, Switzerland. Enrollment for the study described in this protocol commenced in February 2018. Data analysis is currently under way and the first results are expected to be submitted for publication in 2019.
CONCLUSIONS
CONCLUSIONS
This study design helps in comparing the neural activity between conditions in the same individual, thereby addressing a notable limitation of previous EEG tinnitus studies. In addition, the high-frequency assessment will help to analyze and classify tinnitus symptoms beyond the conventional clinical standard.
INTERNATIONAL REGISTERED REPORT IDENTIFIER (IRRID)
UNASSIGNED
RR1-10.2196/12270.
Identifiants
pubmed: 30626571
pii: v8i1e12270
doi: 10.2196/12270
pmc: PMC6329433
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e12270Subventions
Organisme : RNID
ID : 537:NTU:DH
Pays : United Kingdom
Informations de copyright
©Suyi Hu, Lukas Anschuetz, Markus E Huth, Raphael Sznitman, Daniela Blaser, Martin Kompis, Deborah A Hall, Marco Caversaccio, Wilhelm Wimmer. Originally published in JMIR Research Protocols (http://www.researchprotocols.org), 09.01.2019.
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