Rhesus Macaque Rhadinovirus Encodes a Viral Interferon Regulatory Factor To Disrupt Promyelocytic Leukemia Nuclear Bodies and Antagonize Type I Interferon Signaling.
Animals
Cell Line
Herpesvirus 8, Human
/ genetics
Humans
Immunity, Innate
/ genetics
Interferon Regulatory Factor-3
/ genetics
Interferon Regulatory Factors
/ genetics
Interferon Type I
/ genetics
Intranuclear Inclusion Bodies
/ genetics
Leukemia, Promyelocytic, Acute
/ genetics
Macaca mulatta
/ virology
Receptors, Interferon
/ genetics
Rhadinovirus
/ genetics
Signal Transduction
/ genetics
Transcription, Genetic
/ genetics
Viral Proteins
/ genetics
Virus Replication
/ genetics
PML
R12
gammaherpesvirus
innate immunity
interferon
rhadinovirus
vIRF
Journal
Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724
Informations de publication
Date de publication:
15 03 2019
15 03 2019
Historique:
received:
02
12
2018
accepted:
03
01
2019
pubmed:
11
1
2019
medline:
20
11
2019
entrez:
11
1
2019
Statut:
epublish
Résumé
Interferon (IFN) production and the subsequent induction of IFN-stimulated genes (ISGs) are highly effective innate strategies utilized by cells to protect against invading pathogens, including viruses. Critical components involved in this innate process are promyelocytic leukemia nuclear bodies (PML-NBs), which are subnuclear structures required for the development of a robust IFN response. As such, PML-NBs serve as an important hurdle for viruses to overcome to successfully establish an infection. Both Kaposi's sarcoma-associated herpesvirus (KSHV) and the closely related rhesus macaque rhadinovirus (RRV) are unique for encoding viral homologs of IFN regulatory factors (termed vIRFs) that can manipulate the host immune response by multiple mechanisms. All four KSHV vIRFs inhibit the induction of IFN, while vIRF1 and vIRF2 can inhibit ISG induction downstream of the IFN receptor. Less is known about the RRV vIRFs. RRV vIRF R6 can inhibit the induction of IFN by IRF3; however, it is not known whether any RRV vIRFs inhibit ISG induction following IFN receptor signaling. In our present study, we demonstrate that the RRV vIRF R12 aids viral replication in the presence of the type I IFN response. This is achieved in part through the disruption of PML-NBs and the inhibition of robust ISG transcription.
Identifiants
pubmed: 30626678
pii: JVI.02147-18
doi: 10.1128/JVI.02147-18
pmc: PMC6401433
pii:
doi:
Substances chimiques
Interferon Regulatory Factor-3
0
Interferon Regulatory Factors
0
Interferon Type I
0
Receptors, Interferon
0
Viral Proteins
0
viral interferon regulatory factors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIH HHS
ID : P51 OD011092
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI007472
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI074494
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA075922
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA206404
Pays : United States
Informations de copyright
Copyright © 2019 American Society for Microbiology.
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