A tumor-specific endogenous repetitive element is induced by herpesviruses.
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
09 01 2019
09 01 2019
Historique:
received:
14
12
2017
accepted:
29
11
2018
entrez:
11
1
2019
pubmed:
11
1
2019
medline:
6
2
2019
Statut:
epublish
Résumé
Tandem satellite repeats account for 3% of the human genome. One of them, Human Satellite II (HSATII), is highly expressed in several epithelial cancers and cancer cell lines. Here we report an acute induction of HSATII RNA in human cells infected with two herpes viruses. We show that human cytomegalovirus (HCMV) IE1 and IE2 proteins cooperate to induce HSATII RNA affecting several aspects of the HCMV replication cycle, viral titers and infected-cell processes. HSATII RNA expression in tissue from two chronic HCMV colitis patients correlates with the strength of CMV antigen staining. Thus, endogenous HSATII RNA synthesis after herpesvirus infections appears to have functionally important consequences for viral replication and may provide a novel insight into viral pathogenesis. The HSATII induction seen in both infected and cancer cells suggests possible convergence upon common HSATII-based regulatory mechanisms in these seemingly disparate diseases.
Identifiants
pubmed: 30626867
doi: 10.1038/s41467-018-07944-x
pii: 10.1038/s41467-018-07944-x
pmc: PMC6327058
doi:
Substances chimiques
RNA
63231-63-0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
90Subventions
Organisme : NCI NIH HHS
ID : R01 CA240924
Pays : United States
Organisme : NIH HHS
ID : 1P30CA196521-01
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI081848
Pays : United States
Organisme : NIAID NIH HHS
ID : R56 AI112951
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI112951
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA196521
Pays : United States
Organisme : NIH HHS
ID : 7R01AI081848-04
Pays : United States
Organisme : NIH HHS
ID : AI112951
Pays : United States
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