Characterization of Corneal Epithelial Cells in Keratoconus.
apoptosis
corneal crosslinking
corneal epithelial cells
epithelial-mesenchymal transition
keratoconus
proliferation
Journal
Translational vision science & technology
ISSN: 2164-2591
Titre abrégé: Transl Vis Sci Technol
Pays: United States
ID NLM: 101595919
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
01
05
2018
accepted:
09
11
2018
entrez:
11
1
2019
pubmed:
11
1
2019
medline:
11
1
2019
Statut:
epublish
Résumé
We studied the cellular characteristics of epithelial cells in the cone and extraconal periphery of corneas in keratoconus eyes. This prospective observational study was conducted at Narayana Nethralaya Eye Institute. A total of 83 and 42 eyes with keratoconus and normal topography, respectively, were included in the study. Corneal epithelial cells were collected and analyzed for apoptosis, proliferation, epithelial-mesenchymal transition, and differentiation status using molecular and biochemical tools. Statistical analysis was performed using the Student's Corneal epithelial cells from the cone showed significantly higher expression of proapoptotic marker BAX ( Cones of keratoconic corneas show enhanced cell death, poor differentiation, proliferation and epithelial-mesenchymal transition. The cellular changes of the corneal epithelial cells in the cone and extraconal region differ significantly in a keratoconus corneas. Characterization of patient-specific corneal epithelial cellular status in keratoconus has the potential to determine the optimal treatment and therapeutic outcomes paving the way towards personalized treatment in the future.
Identifiants
pubmed: 30627477
doi: 10.1167/tvst.8.1.2
pii: TVST-18-0864
pmc: PMC6322712
doi:
Types de publication
Journal Article
Langues
eng
Pagination
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