Antagonistic effects of Plasmodium-helminth co-infections on malaria pathology in different population groups in Côte d'Ivoire.
Adolescent
Adult
Aged
Aged, 80 and over
Anemia
/ epidemiology
Child
Child, Preschool
Coinfection
/ pathology
Cote d'Ivoire
Cross-Sectional Studies
Female
Hookworm Infections
/ complications
Humans
Malaria
/ complications
Male
Middle Aged
Population Groups
Pregnancy
Schistosomiasis
/ complications
Splenomegaly
/ epidemiology
Young Adult
Journal
PLoS neglected tropical diseases
ISSN: 1935-2735
Titre abrégé: PLoS Negl Trop Dis
Pays: United States
ID NLM: 101291488
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
15
08
2018
accepted:
17
12
2018
revised:
23
01
2019
pubmed:
11
1
2019
medline:
12
2
2019
entrez:
11
1
2019
Statut:
epublish
Résumé
Plasmodium spp. and helminths are co-endemic in many parts of the tropics; hence, co-infection is a common phenomenon. Interactions between Plasmodium and helminth infections may alter the host's immune response and susceptibility and thus impact on morbidity. There is little information on the direction and magnitude of such interactions and results are conflicting. This study aimed at shedding new light on the potential interactions of Plasmodium and helminth co-infections on anemia and splenomegaly in different population groups in Côte d'Ivoire. Parasitologic and clinical data were obtained from four cross-sectional community-based studies and a national school-based survey conducted between 2011 and 2013 in Côte d'Ivoire. Six scenarios of co-infection pairs defined as Plasmodium infection or high parasitemia, combined with one of three common helminth infections (i.e., Schistosoma mansoni, S. haematobium, and hookworm) served for analysis. Adjusted logistic regression models were built for each scenario and interaction measures on additive scale calculated according to Rothman et al., while an interaction term in the model served as multiplicative scale measure. All identified significant interactions were of antagonistic nature but varied in magnitude and species combination. In study participants aged 5-18 years from community-based studies, Plasmodium-hookworm co-infection showed an antagonistic interaction on additive scale on splenomegaly, while Plasmodium-Schistosoma co-infection scenarios showed protective effects on multiplicative scale for anemia and splenomegaly in participants aged 5-16 years from a school-based study. No exacerbation from co-infection with Plasmodium and helminths was observed, neither in participants aged 5-18 years nor in adults from the community-based studies. Future studies should unravel underlying mechanisms of the observed interactions, as this knowledge might help shaping control efforts against these diseases of poverty.
Identifiants
pubmed: 30629580
doi: 10.1371/journal.pntd.0007086
pii: PNTD-D-18-01254
pmc: PMC6343929
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0007086Subventions
Organisme : Wellcome Trust
ID : 107753/A/15/Z
Pays : United Kingdom
Déclaration de conflit d'intérêts
The authors have declared that no competing interests exist.
Références
Curr Opin HIV AIDS. 2012 May;7(3):231-8
pubmed: 22418448
Am J Trop Med Hyg. 2014 Feb;90(2):329-34
pubmed: 24323515
Clin Microbiol Rev. 2009 Jan;22(1):13-36, Table of Contents
pubmed: 19136431
Malar J. 2015 Jan 05;14:7
pubmed: 25559587
Acta Trop. 2008 Nov-Dec;108(2-3):109-17
pubmed: 18577364
Acta Trop. 2010 Jul-Aug;115(1-2):103-11
pubmed: 20175980
PLoS Negl Trop Dis. 2012;6(7):e1723
pubmed: 22848765
PLoS Negl Trop Dis. 2018 May 10;12(5):e0006483
pubmed: 29746467
Am J Epidemiol. 1980 Oct;112(4):467-70
pubmed: 7424895
Parasitology. 2008 Jun;135(7):783-94
pubmed: 18371242
Immunobiology. 2013 May;218(5):706-11
pubmed: 22999162
PLoS Negl Trop Dis. 2018 Aug 6;12(8):e0006663
pubmed: 30080853
PLoS Negl Trop Dis. 2014 Sep 11;8(9):e3154
pubmed: 25210876
J Helminthol. 2016 May;90(3):337-41
pubmed: 25989836
Int J Epidemiol. 2007 Oct;36(5):1111-8
pubmed: 17726040
Parasitol Today. 2000 Nov;16(11):469-76
pubmed: 11063857
Rev Inst Med Trop Sao Paulo. 1972 Nov-Dec;14(6):397-400
pubmed: 4675644
Parasit Vectors. 2015 Oct 20;8:545
pubmed: 26482351
Am J Trop Med Hyg. 2003 Jan;68(1):24-32
pubmed: 12556143
PLoS Negl Trop Dis. 2011 Aug;5(8):e1149
pubmed: 21912707
Ann Trop Paediatr. 2010;30(1):1-17
pubmed: 20196929
Nat Immunol. 2013 Nov;14(11):1118-1126
pubmed: 24145791
Int J Parasitol. 2011 Aug 15;41(10):1041-51
pubmed: 21777589
Am J Trop Med Hyg. 2011 May;84(5):792-800
pubmed: 21540391
J Infect Dis. 2011 Feb 1;203(3):406-17
pubmed: 21187338
Trans R Soc Trop Med Hyg. 2013 Nov;107(11):672-83
pubmed: 24123127
Bull Soc Pathol Exot. 2007 Aug;100(3):176-7
pubmed: 17824309
Int J Epidemiol. 2015 Feb;44(1):87-97
pubmed: 25433704
Parasit Vectors. 2012 Jul 06;5:135
pubmed: 22768986
Lancet. 2014 Feb 22;383(9918):723-35
pubmed: 23953767
Acta Trop. 2011 Oct-Nov;120(1-2):95-102
pubmed: 21741929
Trop Med Int Health. 2005 Jan;10(1):42-57
pubmed: 15655013
PLoS Negl Trop Dis. 2010 Dec 21;4(12):e910
pubmed: 21200423
Malar J. 2016 Jan 06;15:9
pubmed: 26739224
Am J Trop Med Hyg. 2005 Jun;72(6):702-7
pubmed: 15964953
Am J Clin Nutr. 2015 Mar;101(3):462-70
pubmed: 25733630
Trop Med Int Health. 2007 Dec;12(12):1442-9
pubmed: 18076550
Parasit Vectors. 2014 Feb 25;7:81
pubmed: 24568206
Eur J Epidemiol. 2011 Jun;26(6):433-8
pubmed: 21344323
PLoS Negl Trop Dis. 2015 Oct 29;9(10):e0004193
pubmed: 26513151
Trop Med Int Health. 2010 Jan;15(1):105-12
pubmed: 19968840
Am J Clin Nutr. 2010 Dec;92(6):1385-92
pubmed: 20926522
Matern Child Nutr. 2008 Apr;4 Suppl 1:118-236
pubmed: 18289159
PLoS Negl Trop Dis. 2014 Jun 05;8(6):e2913
pubmed: 24901333
Am J Clin Nutr. 1997 Aug;66(2):464S-477S
pubmed: 9250134
Acta Trop. 2013 Nov;128(2):261-74
pubmed: 23041540
J Parasitol. 2006 Dec;92(6):1191-5
pubmed: 17304793
Anemia. 2011;2011:260380
pubmed: 21738863
PLoS Negl Trop Dis. 2014 Dec 04;8(12):e3287
pubmed: 25474579
Am J Trop Med Hyg. 2007 Dec;77(6 Suppl):88-98
pubmed: 18165479
Parasite Immunol. 2009 Feb;31(2):64-71
pubmed: 19149774
PLoS Negl Trop Dis. 2013 Sep 12;7(9):e2431
pubmed: 24069486
Adv Parasitol. 2010;73:21-50
pubmed: 20627138
PLoS Negl Trop Dis. 2012;6(11):e1889
pubmed: 23133691
PLoS Negl Trop Dis. 2008 Jun 04;2(6):e245
pubmed: 18523547
PLoS One. 2014 Jan 29;9(1):e86510
pubmed: 24489732
Am J Trop Med Hyg. 2005 Dec;73(6):1124-30
pubmed: 16354824