Regio- and Stereoselective Synthesis of Functionalized Dihydropyridines, Pyridines, and 2H-Pyrans: Heck Coupling of Monocyclopropanated Heterocycles.
2H-pyrans
Heck coupling
arylpyridines
dihydropyridines
donor-acceptor cyclopropanes
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
11 03 2019
11 03 2019
Historique:
received:
02
12
2018
revised:
02
01
2019
pubmed:
11
1
2019
medline:
11
1
2019
entrez:
11
1
2019
Statut:
ppublish
Résumé
A palladium-catalyzed coupling between aryl halides and monocyclopropanated pyrroles or furans has been developed, leading to valuable six-membered N- and O-heterocycles. As the key step, a selective cleavage of the non-activated endocyclic C-C bond of the 2-heterobicyclo-[3.1.0]hexane framework is achieved. The developed method offers access to highly functionalized piperidines, pyridines, and pyrans that are challenging to access by traditional methods.
Identifiants
pubmed: 30629786
doi: 10.1002/anie.201813716
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
3594-3598Subventions
Organisme : Deutscher Akademischer Austauschdienst
ID : Ph.D. fellowship
Pays : International
Organisme : Deutsche Forschungsgemeinschaft
ID : GRK 1910
Pays : International
Informations de copyright
© 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.