Isochoric conditions enable high subfreezing temperature pancreatic islet preservation without osmotic cryoprotective agents.
Cryoprotective agents
Isochoric cryopreservation
Organ cryopreservation
Pancreatic islets
Journal
Cryobiology
ISSN: 1090-2392
Titre abrégé: Cryobiology
Pays: Netherlands
ID NLM: 0006252
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
29
10
2018
revised:
06
12
2018
accepted:
04
01
2019
pubmed:
11
1
2019
medline:
19
12
2019
entrez:
11
1
2019
Statut:
ppublish
Résumé
While biological systems are typically studied under isobaric (constant pressure) conditions, recent reports on the bio-thermodynamics of isochoric (constant volume) systems point to their potential for subfreezing-temperature preservation of biological matter. This preliminary study, in which we report that pancreatic islets can survive multi-day preservation at high subfreezing temperatures in an isochoric chamber without osmotic cryoprotective agents (CPA), highlights the potential of isochoric cryopreservation in an application of clinical value.
Identifiants
pubmed: 30629949
pii: S0011-2240(18)30597-2
doi: 10.1016/j.cryobiol.2019.01.003
pii:
doi:
Substances chimiques
Cryoprotective Agents
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
130-133Informations de copyright
Copyright © 2019 Elsevier Inc. All rights reserved.